Types A and B Niemann-Pick disease (NPD) are lipid storage disorders caused by the deficient activity of acid sphingomyelinase (ASM). In humans, NPD is associated with the dysfunction of numerous organs including the lung. Gene targeting of the ASM gene in transgenic mice produced an animal model with features typical of NPD, including pulmonary inflammation. To assess mechanisms by which ASM p...

Emotions form part of the fabric of our minds, and the scientific attempts to map these dimensions onto the underlying neural substrates date back to the first half of the last century. It has long been suggested that emotional functions are associated with subcortical structures (e. was the first to postulate that emotional processing is based on an interconnected cortical-subcortical system, ...

Preilowski B. Cortical and subcortical afferent connections of the primate's temporal pole. A study using rhesus monkeys, squirrel monkeys, and marmosets. The amyg-dala's contribution to memory-a PET-study on two patients with Urbach-Wiethe disease. The effect of organic brain disease on recall of emotionally charged versus neutral narrative texts. The quality of doctors' writing has long been ...

We present density-functional theory calculations of the optical absorption spectra of silica glass for temperatures up to 2400 K. The calculated spectra exhibit exponential tails near the fundamental absorption edge that follow the Urbach rule in good agreement with experiments. We discuss the accuracy of our results by comparing to hybrid exchange correlation functionals. We show that the Urb...

Investigation of new calculate depends on the controlled optical properties of nanomaterials. Understanding the growth mechanism and growth parameters of nanostructured materials is essential. ZnO is one of the most important semiconductor materials for its semiconducting characteristics. In the present paper, we investigated a new model by theoretical methods; it is based on correlation from t...

Lipoid proteinosis is a rare hereditary metabolic disorder transmitted as an autosomal recessive trait. It is characterized by the deposition of an amorphous hyaline-like material (glycoprotein) in the mucous membranes, skin and various internal organs. Cryosurgery (N(2)O) was applied to remove and reshape the lip lesions in a case of this rare syndrome. The patient was a 24-year-old female. Cr...

F rom an evolutionary perspective, facial expressions of fear convey highly recognizable emotional signals that serve adaptive functions by promoting survival and reproductive success (1). Current theories of how the brain interprets facial expressions of fear implicate the mirror neuron network (MNN) in echoing the emotional states of others by internal simulation (2,3). Originally discovered ...

Lipoid proteinosis (LP) is a rare autosomal recessive disorder. Classical clinical features include warty skin infiltration, papules on the eyelids, skin scarring, as well as extracutaneous abnormalities such as hoarseness of the voice, epilepsy, and neuropsychiatric abnormalities. A defect in the ECM1 gene is responsible for this disease. A 21-year-old female patient from consanguineous ...

Human epidemiologic studies have found that silicosis may develop or progress even after occupational exposure has ended, suggesting that there is a threshold lung burden above which silica-induced pulmonary disease progresses without further exposure. We previously described the time course of rat pulmonary responses to silica inhalation as biphasic, the initial phase characterized by increase...