Soft-tissue sarcomas are heterogeneous cancers that can present with tissue-specific differentiation markers. To examine the cellular basis for this histopathological variation and to identify sarcoma-relevant molecular pathways, we generated a chimeric mouse model in which sarcoma-associated genetic lesions can be introduced into discrete, muscle-resident myogenic and mesenchymal cell lineages...

Primary sarcomas of the aorta are extremely uncommon. Depending on histomorphology and immunohistochemical pattern, intimal sarcomas can show angiosarcomatous differentiation. Here, we describe the case of a 60-year-old woman with a primary intimal sarcoma of the aortic arch and signs of cerebral metastatic disease as the initial manifestation. After the patient experienced the onset of severe ...

Primary hepatic undifferentiated pleomorphic sarcoma (UPS) is an extremely rare disease entity whose imaging characteristics are not well documented in literature. We present two cases of primary hepatic UPS with contrasting disease courses, and their CT and angiographic findings in this report. Imaging characteristics include inhomogeneous appearance and peripheral enhancement pattern, with ne...

Uterine sarcomas are rare, aggressive mesenchymal tumours with a relatively poor prognosis. The term comprises various histological subtypes, such as leiomyosarcoma, endometrial stromal sarcomas as well as undifferentiated uterine sarcomas, which require different operative and systemic/radiation therapy strategies accordingly. The evidence on operative, adjuvant and palliative treatment curren...

Primary anterior mediastinum undifferentiated high grade pleomorphic sarcoma is rare that most physician including thoracic surgeon would not experience this disease. Huge anterior mediastinum tumor pressed the heart and it invaded into the left pulmonary arterial trunk. We did the mediastinum tumor resection, left pneumonectomy and left phrenic, sympathetic and vagus nerve merger excision. But...

Primary cardiac sarcoma is a rare malignant tumor that arises from the myocardium. Surgical resection standard of care, and median survival ranges 6 to 12 months. The role salvage chemotherapy radiation not well defined. A 53-year-old female presented with acute congestive heart failure underwent complete surgical an undifferentiated pleomorphic left atrium, followed by six cycles adjuvant doxo...