Background: Deferasirox is an orally bioavailable synthetic, tridentate iron chelator that binds iron at a 2:1 ratio. The generic brand for this drug is still not available in Indonesia. We aimed to compare the efficacy between the generic drug and its innovator (Exjade®) by a study of bioequivalence in Indonesia among healthy volunteers. Methods: An open-label, single-dose, two-sequence, rand...

There is a need for simple and inexpensive methods to quantify potentially harmful persistent pesticides often found in our water-ways and water distribution systems. This paper presents a simple, relatively inexpensive method for the detection of a group of commonly used pesticides (atrazine, simazine and hexazinone) in natural waters using large-volume direct injection high performance liquid...

A chromatographic method for the identification of glycerol derivatives, particularly glyceraldehyde, dihydroxyacetone, mesoxalic, tartronic, glycolic and glyceric acids on an ion-exchange 8% crosslinked calcium sulfonated divinylbenzene-styrene resin column was developed and validated. The experiments included a systematic study of the effect of column temperature (60, 70 °C); flow rate (0.2, ...

BACKGROUND Evaluation of exposition to Volatile Organic Compounds (VOC) and compare urinary level of urinary biological exposure index in sweepers in West of Iran. METHODS This study was carried out on 40 street sweepers and 40 non-exposed as control group living in Hamadan City, west of Iran. VOC was analyzed using gas chromatography equipped with a Flame Ionization Detector (FID). The urina...

BACKGROUND The aims of this study were evaluation of exposed to xylenes in low concentration and compare urinary level of methyl hippuric acid in taxi drivers and petrol stations workers in West of Iran. METHODS This observation study was carried out on samples of the exposed men to xylenes in two occupational groups in Hamadan City (west of Iran) from March 2003 to March 2004. Subjects inclu...

We have developed a simplified and improved high performance liquid chromatography (HPLC) method for the detection and quantitation of tissue lipid using a new laser light-scattering detector (Varex model ELSD II). This detector has a limit of sensitivity of 50 ng for neutral lipid and 200 ng for most phospholipids with excellent reproducibility. By coupling the ELSD II with a ternary gradient ...

Fenarimol (Rubigan) is a pyrimidine ergosterol biosynthesis inhibitor used as a systemic fungicide. The authors present a fatal fenarimol intoxication case analysed in the Forensic Toxicology Service of the National Institute of Legal Medicine. The results were used to compare two different HPLC techniques, regarding selectivity and sensitivity: an HPLC system with a diode array detector (DAD) ...

Non-targeted strategies based on high-performance liquid chromatography with ultraviolet detection (HPLC-UV) and fluorescence (HPLC-FLD) fingerprints were evaluated to accomplish the classification authentication of instant coffee (40 samples), decaf (26 chicory (22 samples, including both ground instant), as well detect quantify frauds adulteration by multivariate chemometric methods. HPLC-UV ...