The induction of lesions in DNA by combinations of benzo(a)pyrene (B(a)P) and near-ultraviolet light (NUV) with wavelengths of 300 to 480 nm was investigated. Using centrif ugal methods or agarose gel electrophoretic techniques to monitor the conversion of the superhelical double-stranded PM2 DNA to the relaxed circular form, it was possible to quantitate the rates of single-strand breakage in ...

Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage ...

BACKGROUND Published studies assessing whether asymmetrical facial ultraviolet light exposure leads to underlying differences in skin physiology and morphology report only clinical observations. The aim of this study was to assess the visual impact on the skin of repeated ultraviolet-A (UVA) exposure through a window. METHODS Eight women and two men presenting with asymmetrical signs of photo...

OBJECTIVE To assess the risk of lymphoma in patients with psoriasis. DESIGN Prospective cohort study that spans 30 years and a systematic review of the literature. SETTING Sixteen university medical centers. PATIENTS A total of 1380 patients with psoriasis who were initially treated with psoralen-UV-A (PUVA) from 1975 through 1976 and who underwent periodic interviews and physician examin...

To determine whether platelet-rich fibrin lysate (PRF-L) could restore the function of chronically ultraviolet-A (UVA)-irradiated human dermal fibroblasts (HDFs), we isolated and sub-cultured HDFs from six different human foreskins. HDFs were divided into two groups: those that received chronic UVA irradiation (total dosages of 10 J cm⁻²) and those that were not irradiated. We compared the prol...

CONTEXT Each year tens of thousands of patients in the United States are treated with UV-B radiation or psoralen plus UV-A radiation (PUVA) for a variety of skin disorders. Although PUVA is generally considered more effective, it is also more toxic and more expensive. The degree of consensus among experts in prescribing these alternative treatments has not been quantified. OBJECTIVES To quant...

Attenuation of UV-B radiation in the water column occurs due to absorption and scatter but in shallow clear freshwater systems enhanced UV-B radiation might be of importance in affecting aquatic organisms. Two laboratory experiments were performed to determine whether two species of charophytes typical for shallow waterbodies, such as Chara polyacantha and Nitella hyalina, are negatively affect...

OBJECTIVE To assess the costs and cost effectiveness of phototherapy with ultraviolet B light provided at home compared with outpatient ultraviolet B phototherapy for psoriasis. DESIGN Cost utility, cost effectiveness, and cost minimisation analyses performed alongside a pragmatic randomised clinical trial (the PLUTO study) at the end of phototherapy (mean 17.6 weeks) and at one year after th...