نتایج جستجو برای: ugt1a1 gene

تعداد نتایج: 1141874  

Journal: :Human molecular genetics 2009
Andrew D Johnson Maryam Kavousi Albert V Smith Ming-Huei Chen Abbas Dehghan Thor Aspelund Jing-Ping Lin Cornelia M van Duijn Tamara B Harris L Adrienne Cupples Andre G Uitterlinden Lenore Launer Albert Hofman Fernando Rivadeneira Bruno Stricker Qiong Yang Christopher J O'Donnell Vilmundur Gudnason Jacqueline C Witteman

Variation in serum bilirubin is associated with altered cardiovascular disease risk and drug metabolism. We aimed to identify genetic contributors to variability in serum bilirubin levels by combining results from three genome-wide association studies (Framingham heart study, n = 3424; Rotterdam study, n = 3847; Age, Gene, Environment and Susceptibility-Reykjavik, n = 2193). Meta-analysis showe...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Cody J Peer Tristan M Sissung Aerang Kim Lokesh Jain Sukyung Woo Erin R Gardner C Tyler Kirkland Sarah M Troutman Bevin C English Emily D Richardson Joel Federspiel David Venzon William Dahut Elise Kohn Shivaani Kummar Robert Yarchoan Giuseppe Giaccone Brigitte Widemann William D Figg

PURPOSE Several case reports suggest sorafenib exposure and sorafenib-induced hyperbilirubinemia may be related to a (TA)(5/6/7) repeat polymorphism in UGT1A1*28 (UGT, uridine glucuronosyl transferase). We hypothesized that sorafenib inhibits UGT1A1 and individuals carrying UGT1A1*28 and/or UGT1A9 variants experience greater sorafenib exposure and greater increase in sorafenib-induced plasma bi...

Journal: :Genetics and molecular research : GMR 2016
J Shi L H Li X Y Duan Q Liu L L Sun Y T Tian

Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymorphisms have been identified in the UGT1A...

2017
Xuewei Cheng Xia Lv Hengyan Qu Dandan Li Mengmeng Hu Wenzhi Guo Guangbo Ge Ruihua Dong

UDP-glucuronosyltransferase 1A1 (UGT1A1) plays a key role in detoxification of many potentially harmful compounds and drugs. UGT1A1 inhibition may bring risks of drug-drug interactions (DDIs), hyperbilirubinemia and drug-induced liver injury. This study aimed to investigate and compare the inhibitory effects of icotinib and erlotinib against UGT1A1, as well as to evaluate their potential DDI ri...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008
Tim O Lankisch Christoph Schulz Thomas Zwingers Thomas J Erichsen Michael P Manns Volker Heinemann Christian P Strassburg

BACKGROUND Gilbert's syndrome is characterized by a functional promoter single nucleotide polymorphism (SNP) of the UDP-glucuronosyltransferase (UGT) 1A1 gene and represents a pharmacogenetic risk factor for irinotecan toxicity, but study data remain controversial. The active CPT-11 metabolite 7-ethyl-10-hydroxycamptothecin is detoxified by several UGT1A proteins, which include UGT1A7 with a hi...

Journal: :Anticancer research 2004
Tetsuya Oguri Toshiaki Takahashi Mitsuru Miyazaki Takeshi Isobe Nobuoki Kohno Peter I Mackenzie Yasuhiro Fujiwara

BACKGROUND We previously reported that upregulation of glucuronidation activity catalyzed by uridine 5'diphosphoglucuronosyltransferase (UGT) is one of the mechanisms associated with irinotecan hydrochloride/7-ethyl-10-hydroaxycamptothecin (CPT-11/SN-38) resistance. In order to extend this result to the clinical setting, it is important to elucidate the role of SN-38 glucuronidation by UGT1A is...

2017
Arnaud Jannin Benjamin Hennart Antoine Adenis Bruno Chauffert Nicolas Penel

Alveolar rhabdomyosarcoma (AR) in adult patients is an exceptional malignancy. Management of AR is based on (neo)adjuvant chemotherapy combining ifosfamide, vincristine, and actinomycin D and local curative-intent surgery/radiotherapy. In cases of relapsing AR, the combination of temozolomide/irinotecan is regarded as a possible option. Here we describe life-threatening long-lasting toxicity re...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2007
Donglu Zhang Duxi Zhang Dan Cui Janice Gambardella Li Ma Anthony Barros Lifei Wang Yunlin Fu Sandhya Rahematpura Julia Nielsen Michael Donegan Hongjian Zhang W Griffith Humphreys

The UGT1A1*28 polymorphism is known to correlate with altered clearance of bilirubin (Gilbert syndrome) and drugs such as 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin (CPT-11). Although this polymorphism is clinically relevant and leads to significant drug-related toxicity of CPT-11, in vitro tools to allow prediction of how it will affect the clearance of new chemical en...

2016
JINLI BAI YUJIN QU YANYAN CAO YAN LI WENHUI ZHANG YUWEI JIN HONG WANG FANG SONG

X-linked ichthyosis (XLI) is an X-linked recessive skin disorder generally restricted to males, which arises from mutations in the steroid sulfatase (STS) gene located on Xp22.3. Crigler-Najjar syndrome (CN-I) is a rare autosomal recessive disease caused by the homozygous or compound heterozygous mutations in the UPD‑glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) gene on chromosome 2...

Journal: :Haematologica 2005
Vicky Chaar Lysiane Kéclard Jean Pierre Diara Claudine Leturdu Jacques Elion Rajagopal Krishnamoorthy John Clayton Marc Romana

BACKGROUND AND OBJECTIVES High levels of erythrocyte destruction in sickle cell anemia (SCA) result in chronic hyperbilirubinemia, with cholelithiasis occurring in a subset of patients. We investigated whether susceptibility to cholelithiasis in SCA was associated with the promoter polymorphism of the 5?-diphosphate-glucuronosyltransferase 1A1 (UGT1A1) gene encoding a key enzyme in bilirubin ca...

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