introduction: dill (anethum graveolens), a herb from from umbelliferae, is used traditionally to treat convulsion and increasing milk production. its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. the spasmolytic effect of dill fruit on rat uterus has also been shown recently. the aim of present study was to i...

Previous studies indicate that Matricaria chamomilla (MC), a folk remedy plant, is very useful in the treatment of spasmogenic bowel diseases but the way of its action is not clear. For this purpose, we studied the effect of MC extract on the electrically activation in Guinea-Pig ileum in an invitro model. We used guinea pig in this study. After of kill, we brouhght out a piece of ileum and fix...

Introduction: Dill (Anethum graveolens), a herb from from Umbelliferae, is used traditionally to treat convulsion and increasing milk production. Its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. The spasmolytic effect of dill fruit on rat uterus has also been shown recently. The aim of present study was to i...

Pharmacognosy Research,2022,14,4,492-498.DOI:10.5530/pres.14.4.71Published:October 2022Type:Original ArticleAuthors:Adaobi C. Ezike, Nwoyi N. Bassey, Emenike Amah, Daniel U. Nwankpa, Aniebiet E. Samuel, and John O. Medewase Author(s) affiliations:Adaobi Ezike*, Department of Pharmacology Toxicology, Faculty Pharmaceutical Sciences, University Nigeria, Nsukka, Enugu, NIGERIA. Abstract:Background...

BACKGROUND Disturbances in intracellular pH (pHi) of the heart can trigger major changes in the strength and rhythm of the heartbeat. It is well known that two extruders, Na+/H+ exchange (NHE) and Na+/HCO3- symporter (NHS), and a monocarboxylic acid transporter (MCT) are involved in acid-equivalent extruding in the human heart. Drinking alcohol has been proven to affect blood pressure and heart...

The ionic mechanism underlying the shortening of the action potential and the reduction in pacemaker activity by lidocaine, quinidine, and procainamide in sheep cardiac Purkinje fibers was investigated using the two-microelectrode voltage clamp technique. In the presence of lidocaine (1.85 to 3.7 x 10"M), steady state currents were shifted outward over a broad range of potentials. In contrast, ...

Calcium Dynamics and Ventricular Fibrillation To the Editor: Warren et al1 recently performed an optical mapping study in blood-perfused pig hearts. They concluded that their results did not support the presence of nonvoltage-gated intracellular calcium (Cai) transients during ventricular fibrillation (VF) and suggested that action potential (AP)/Cai transient dissociation is a consequence rath...

It is generally assumed that in cardiac Purkinje fibers the hyperpolarization activated inward current i(f) underlies the pacemaker potential. Because some findings are at odds with this interpretation, we used the whole cell patch clamp method to study the currents in the voltage range of diastolic depolarization in single canine Purkinje myocytes, a preparation where many confounding limitati...

Previous studies indicate that Matricaria chamomilla (MC), a folk remedy plant, is very useful in the treatment of spasmogenic bowel diseases but the way of its action is not clear. For this purpose, we studied the effect of MC extract on the electrically activation in Guinea-Pig ileum in an invitro model. We used guinea pig in this study. After of kill, we brouhght out a piece of ileum and fix...