نتایج جستجو برای: tyr3

تعداد نتایج: 264  

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2015
Esther I van Vliet Casper H van Eijck Ronald R de Krijger Elisabeth J Nieveen van Dijkum Jaap J Teunissen Boen L Kam Wouter W de Herder Richard A Feelders Bert A Bonsing Tessa Brabander Eric P Krenning Dik J Kwekkeboom

UNLABELLED Pancreatic neuroendocrine tumors (NETs) are rare neoplasms for which surgery has almost the only potential for cure. When surgery is not possible because of tumor size and vascular involvement, neoadjuvant treatment with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-octreotate) may be an option. METHODS We studied 29 Dutch patients with a pathology-proven nonfunctioning pancreatic NE...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2017
Tessa Brabander Wouter A van der Zwan Jaap J M Teunissen Boen L R Kam Richard A Feelders Wouter W de Herder Casper H J van Eijck Gaston J H Franssen Eric P Krenning Dik J Kwekkeboom

Purpose: Bronchial and gastroenteropancreatic neuroendocrine tumors (NET) are slow-growing tumors, which frequently express somatostatin receptors on their cell membranes. These receptors are targets for therapy with Lutetium-177-labeled somatostatin analogues. We have treated over 1,200 patients with peptide receptor radionuclide therapy (PRRT) with [177Lu-DOTA0,Tyr3]octreotate (177Lu-DOTATATE...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
J Brunton S Charpak

Opioidergic inhibition of neurons in the centrolateral nucleus of the thalamus was investigated using an in vitro thalamic slice preparation from young rats. The mu-opioid receptor agonist D-Ala2,N-Me-Phe4,glycinol5-enkephalin (DAMGO) evoked a hyperpolarization and decrease in input resistance that was reversible, concentration-dependent, and persisted in the presence of tetrodotoxin. Applicati...

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