Increased serum levels of IL-15 are reported in type 1 diabetes (T1D). Here we report elevated serum soluble IL-15Rα levels in human T1D. To investigate the role of IL-15/IL-15Rα in the pathogenesis of T1D, we generated double transgenic mice with pancreatic β-cell expression of IL-15 and IL-15Rα. The mice developed hyperglycemia, marked mononuclear cell infiltration, β-cell destruction, and an...

Type 1 diabetes (T1D) is a T cell mediated autoimmune disease characterized by immune mediated destruction of the insulin-producing β cells in the islets of Langerhans. Dendritic cells (DC) have been implicated in the pathogenesis of T1D and are also used as immunotherapeutic agents. Plasmacytoid (p)DC have been shown to have both protective and pathogenic effects and a newly described merocyti...

1051 Type 1 diabetes mellitus (T1D) is well recognized to be associated with a higher incidence and prevalence of atherosclerotic cardiovascular disease (ASCVD). However, randomized clinical trials in which risk factors for ASCVD (blood pressure, lipids, glycemia) have been modified are nonexistent for T1D patients. Thus, any model that is developed must be based on observational data only. The...

Wiberg, A. 2016. Immunopathology of the Pancreas in Type 1 Diabetes. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1263. 53 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9711-8. Type 1 diabetes (T1D) results from a loss of functional insulin-producing pancreatic beta cells. The etiology of T1D is poorly understood, but the detection of infi...

Elevated ratios of circulating unmethylated to methylated preproinsulin (INS) DNA have been suggested to reflect β-cell death in type 1 diabetes (T1D). We tested the hypothesis that absolute levels (rather than ratios) of unmethylated and methylated INS DNA differ between subjects with new-onset T1D and control subjects and assessed longitudinal changes in these parameters. We used droplet digi...

OBJECTIVE To assess whether family involvement and acculturation were related to adherence and glycemic control among Hispanic youth with type 1 diabetes (T1D). METHODS Hispanic youth with T1D (n = 111; M age = 13.33; 53% female) and parents completed questionnaires that assessed diabetes-related family involvement (distribution of responsibility for diabetes, family support for diabetes), ac...

An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN22(R620W), is strongly associated with type 1 diabetes (T1D) in humans and increases the risk of T1D by two- to fourfold. The NOD mouse is a spontaneous T1D model that shares with humans many genetic pathways contributing to T1D. We hypothesized that the introduction of the murine orthologous Ptpn22(R619W) muta...

Diagnosis of type 1 diabetes (T1D) has serious, life changing implications. Learning to understand complex medication regimes and glucose regulation requires support education. Introducing physical activity alongside these complexities brings additional challenges. It is known that levels in children with T1D are generally less than the general population1,2. Understanding energy expenditure ca...

BACKGROUND The functional reproductive alterations seen in women with type 1 diabetes (T1D) have changed as therapy has improved. Historically, patients with T1D and insufficient metabolic control exhibited a high prevalence of amenorrhea, hypogonadism and infertility. This paper reviews the impact of diabetes on the reproductive axis of female T1D patients treated with modern insulin therapy, ...