We present a Monte Carlo simulation study of the distribution and propagation of twist from one DNA linker to another for a two-nucleosome array subjected to externally applied twist. A mesoscopic model of the array that incorporates nucleosome geometry along with the bending and twisting mechanics of the linkers is employed and external twist is applied in stepwise increments to mimic quasista...

The present study investigated the role of the Twist gene in epithelial-mesenchymal transition (EMT) and its effects on the invasion and metastasis of malignant tumors. In vitro, we transfected SW480, HCT116 and HT29 cells with recombinant plasmids, pTracer-CMV/BSD-Twist and pGenesil1.2-Twist-shRNA, to influence expression of Twist. The transfection efficacy of the plasmids in the cell lines wa...

Metal forming processes, compared with machining ones, reduce production steps and increase manufacturing speed in addition to saving raw material. In this paper, forming process of column of a steering mechanism is investigated by finite element analyses and experimental tests; and optimum die design parameters are found. Forming process parameters including die opening angle, bearing length, ...

The Saethre-Chotzen syndrome is characterized by premature fusion of cranial sutures resulting from mutations in Twist, a basic helix-loop-helix (bHLH) transcription factor. We have identified Twist target genes using human mutant calvaria osteoblastic cells from a child with Saethre-Chotzen syndrome with a Twist mutation that introduces a stop codon upstream of the bHLH domain. We observed tha...

Alterations of TWIST-1 expression are often seen in solid tumors and contribute to tumorigenesis and cancer progression. However, studies concerning its pathogenic role in leukemia are scarce. Our study shows that TWIST-1 is overexpressed in bone marrow mononuclear cells of patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Gain-of-function and loss-of-function analy...

BACKGROUND Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cadherin expression. However, few authors have examined the expression of Twist and E-cadherin and their prognostic value in patients with esophageal squamous cell carcinoma (ESCC)...

We study twist-three effects in deeply virtual Compton scattering on an unpolarized spin-1/2 target. A careful definition of observables as Fourier moments w.r.t. the azimuthal angle allows for a clear separation of twist-two and-three effects. Although the latter are power suppressed, they give leading contributions to the twist-three asymmetries and do not affect the twist-two observables.

We study twist-three effects in deeply virtual Compton scattering on an unpolarized spin-1/2 target. A careful definition of observables as Fourier moments w.r.t. the azimuthal angle allows for a clear separation of twist-two and-three effects. Although the latter are power suppressed, they give leading contributions to the twist-three asymmetries and do not affect the twist-two observables.

We sought to characterize the alterations of left ventricular (LV) twist after acute myocardial infarction in humans and to study their relationship to usual parameters of LV function. Systolic LV twist was measured by color tissue Doppler echocardiography (TDE) in 34 patients after anterior myocardial infarction and in 20 controls. In a subset of controls and patients, the assessment of LV twi...

A novel fiber-optic twist sensor based on a dual-polarization distributed Bragg reflector (DBR) fiber grating laser is proposed and experimentally demonstrated. By beating the signal between the two polarizations of the laser which operates at 1543.154 nm, a signal of 30.78 MHz in frequency domain is observed. The twist will change the fiber birefringence, and resulting in the beat frequency va...