نتایج جستجو برای: tumor suppressor genes
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TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters. Depleti...
Soluble proteins must protect their structural integrity from water attack by wrapping interactions which imply the clustering of nonpolar residues around the backbone hydrogen bonds. Thus, poorly wrapped hydrogen bonds constitute defects which have been identified as promoters of protein associations since they favor the removal of hydrating molecules. More specifically, a recent study of our ...
はじめに 悪性腫瘍は今や日本人の死因の第1位 を占める疾患 であり, 過去4半 世紀の間に多くの進歩は見られたも のの, 現代でもその診断や治療は困難であることが多 い. 近年の分子生物学的な手法による遺伝子解析によ り, 癌の発生, 進展は特定の遺伝子群に起こるDNAの 損傷の蓄積 と考えられている. 化学発癌の考え方では 自然環境中に存在する発癌物質や, 自然界の放射線や, 紫外線によりこれらの遺伝子上のDNAの 損傷(=遺 伝子異常)が 引き起こされると考えられる. 癌化しつ つある細胞はしばしばこれらのDNAの 傷を修復する 機能を失っており, これらの異常が癌遺伝子や癌抑制 遺伝子のような特定の遺伝子群におこるがDNAの 損 傷が固定される結果, ある場合は直接, 細胞の増殖や 脱分化が進行し, (細胞の増殖を自動車にたとえれば自 動車のアクセルをかけることになり)そ の結...
The tumor suppressor protein p53, a crucial player in the DNA damage response, is regulated in many ways, most notably through ubiquitination. In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development.
Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.
Research on zebrafish reveals how a tumor suppressor works in two different types of cells, and how hypotonic stress promotes tumor formation when the function of this tumor suppressor is lost.
In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604025) show that Importin-11 traffics the tumor suppressor PTEN into the nucleus and in so doing protects it from cytoplasmic proteins that cause PTEN degradation. This work helps explain the nuclear accumulation of PTEN observed in many healthy tissues and, because Ipo11 mutant mice develop lung tumors, also implic...
Stable molecular changes during cell division without any change in the sequence of DNA molecules is known as epigenetic. Molecular mechanisms involved in this process, including histone modifications, methylation of DNA, protein complex and RNA antisense. Cancer genome changes happen through a combination of DNA hypermethylation, long-term epigenetic silencing with heterozygosis loss and genom...
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