Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I-R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor-alpha (TNF-α) inhibitor agent. We aimed to evaluate whether Ada would prevent the lung tissue from damage development over the I-R process. Materials and Methods:Twenty seven Wistar albino male rats were divided into...

Background: Cytokines are suggested to play a role in periodontitis. Objective: To determine and compare the levels of Interleukin-1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) samples amongst healthy individuals and  those with chronic periodontitis. Further to compare the GCF cytokine levels in three genotype classes defined by the respective gene p...

background: dendritic cells (dcs) are professional antigen presenting cells that have an important role in the initiation of immune response. the use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. objective: in this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and cpg oligonucleotides in inducing d...

Abstract Background Oral potentially malignant lesions (OPML) are suspicious that may turn into malignancy according to the degree of dysplasia. Early diagnosis these allows their treatment before transformation. Saliva is a liquid biopsy can be obtained easily from patient and assessed for biomarkers expression. Our study aimed investigate possibility using salivary serum TNF-α Ki-67 in early ...

Benalu batu (B. medicinalis) is a plant endemic to Central Sulawesi that has been reported possess anticancer, antioxidant, and antiviral activities. The mechanism of action these activities still unclear. This study aimed evaluate the immunostimulatory effect ethanol extract B. medicinalis on an in vivo model by measuring macrophage phagocytotic activity cytokine production tumor necrosis fact...

Background: Cytokines are glycoprotein compounds with an important role in inducing and regulating inflammation. Objectives: The present study aimed to measure the effect of Aloe vera alcoholic extracts on inflammatory cytokines rats fed a high-fat diet. Methods: Forty adult male Wistar were purchased randomly categorized into five groups, including two control groups (control diet (HFD) three ...

Purpose: Chronic otitis media (COM) is one of the common infectious diseases middle ear caused by bacterial or viral pathogens. The purpose present study was to investigate efficacy boric acid (BA) in treatment COM comparing topical 4% and 8% BA applications with systemic ciprofloxacin a Pseudomonas aeruginosa (P. aeruginosa) inoculation-induced model rats.
 Materials Methods: Forty-two Sp...

Obesity is classified as a low-grade chronic inflammatory disease. Obesity-induced inflammation associated with the development of insulin resistance (IR). In this study, we investigated effects Mesembryanthemum crystallinum extract (MCE) on tumor necrosis factor-alpha (TNF-α)-induced and IR in 3T3-L1 adipocytes, well underlying mechanisms. Lipolysis was monitored by oil red O staining. Glucose...

Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant enzymes gene expressions in type 2 diabetic rats.Materials and Methods: Streptozotocin/nicotinamide (STZ/NA) induced diabetic rats were used...