There is a lack of evidence on the clinical utility interferon gamma release assay for identifying latent tuberculosis infection in rural and remote settings.
 In Indigenous communities with known history bacillus Calmette-Guérin vaccination, more positive tests results were reported tuberculin skin test than assay.

tuberculosis is an important opportunistic disease among hiv- infected persons worldwide; from march 1999 to feburery 2001 we had seventeen patients with hiv-infection and tuberculosis. here we are presenting the clinical manifestations, diagnosis, treatment and outcome of them. all of them were male, 11 patients had pulmonary and 5 patients had extrapulmonary (pleural effusion 1, hepatic granu...

T-lymphocytes previously sensitized by an antigen undergo blastic transformation and produce IFN’r when stimulated by the same antigen. We studied the lymphoblastic response to PPD and IFNT production in pleural fluid and peripheral blood of 41 patients (15 with tuberculosis pleural effusion, 13 with nontuberculous pleurisy and positive tuberculin skin test, and 13 with tuberculin-negative nont...

History: This macaque was imported from the Philippines in 1990 to augment the breeding colony at the California Regional Primate Research Center. Four years later she was brought to the attention of the veterinary service because of an equivocal tuberculin reaction and the presence of a skin rash. A follow up skin test using mammalian tuberculin, avian tuberculin and a sterile saline control p...

BACKGROUND Health care workers are exposed to patients with tuberculosis and are at risk of nosocomial infection. The aim of this study was to determine the prevalence and factors associated with latent tuberculosis infection among health care workers in Malaysia and also to evaluate the agreement between Quantiferon TB Gold in tube test with Tuberculin Skin Test. METHODS A cross sectional st...

Screening for latent tuberculosis infection is mandatory before starting anti-tumour necrosis factor treatments, but its diagnosis still poses a challenge. While studies performed in developed countries have demonstrated superior performance of T-cell based interferon-γ release assay (IGRA) compared with the tuberculin skin test, there is a debate about whether this holds true in tuberculosis e...

Abstract Background Bovine tuberculosis (bTB), is a worldwide disease caused by Mycobacterium bovis ( M. ). The success of bTB eradication and control programs based on early detection the removal reactors from herd thus routine testing cull strategy have been applied globally. Since late nineteenth century, Tuberculin Skin Test (TST) has primary antemortem test available to support campaigns. ...

Bovine tuberculosis is an important zoonotic disease transmitted by direct contact, respiratory pathway, ingestion of unpasteurised milk and milk product, raw or undercooked meat. Tuberculosis can be difficult to diagnose based only on the clinical signs. Tuberculosis is usually diagnosed in the field with the tuberculin skin test. Sputum and other body fluids may be collected for microbiologic...

BACKGROUND Phoenix Firefighters have had abnormally high rates of tuberculin skin test (TBST) results on medical surveillance. The objectives of this study were to evaluate our firefighters using QuantiFERON-TB (QFT), comparing the results to their TBST results. METHODS Using QFT results obtained during the study, we compared previously positive TBST responders (Cases) to negative responders ...

BACKGROUND Tuberculosis continues to cause unacceptably high levels of disease and death worldwide. Active preventive strategies are required to improve tuberculosis control and to increase the number of cases treated in developing countries. The aim of this study was to evaluate the utility of the tuberculin skin test (TST) in first-year schoolchildren as a means of increasing the number of tu...