Persons whose reaction to tuberculin has changed from negative to positive are known as tuberculin converters. There is widespread interest in chemotherapy for tuberculin converters as a means of preventing the development of clinical tuberculosis. Drug therapy of this kind is referred to as chemoprophylaxis. The effectiveness of chemoprophylaxis is thought to be greatest when offered to those ...

persons infected with the human immunodeficiency virus (hiv) are particularly susceptible to tuberculosis, either by latent infection reactivation or by a primary infection with rapid progression to active disease. this study was done to determine the frequency of tuberculosis infection among iranian patients with hiv/aids. a total of 262 hiv/aids patients attending all three hiv/aids health ca...

BACKGROUND An inverse association between tuberculin responses and atopy has been observed in Japanese children, indicating that BCG immunisation, subclinical exposure to Mycobacterium tuberculosis without clinical disease, or host characteristics may influence the T helper (Th) lymphocyte balance with decreased atopy as a result. This study was undertaken to determine whether tuberculin reacti...

Tuberculin skin test has been used as an indicator of latent tuberculosis in patients with Rheumatoid Arthritis (RA) before administration of biologicals. Effect of Disease modifying antirheumatic drugs (DMARDs) and steroids on the result of tuberculin skin test (TST) may have important implications in interpretation of results of this test. Objectives. To find the prevalence of positive TST in...

Aim: To determine the prevalence of tuberculosis among traditional milking cows in southern Zambia and isolation of Mycobacterium spp from the tuberculin positive cow's milk. Materials and Methods: A total of 1,025 cows originating from traditional cattle sector, in Mapepe, Magoye, Monze, Batoka, GARTBatoka, Kalomo areas of Zambia, supplying major quantity of milk to milk processors, were teste...

We detected and quantified tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) from monocytes/macrophages (M phi) in the peripheral blood of subjects from three different population groups, i.e., tuberculin-negative healthy subjects, tuberculin-positive healthy subjects, and patients with active pulmonary tuberculosis. TNF-alpha or IL-6 activity in the culture supernatant of these ...

Previous experiments have shown that the growth of ceils explanted from tuberculin-sensitive animals may be inhibited if tuberculin is added to the culture menstrnum (1). Tissue culture techniques also have been employed in studies of the mechanism of action of cortisone. The direct effect of this compound upon such diverse physiologic phenomena as heart muscle contraction (2) and renal tubular...

There have been several reports indicating that cortisone suppresses or “blocks” the tuberculin skin reaction in man and experimental animals.1-3 Also it has been shown that ACTH or cortisone inhibits the development of the Arthus phenomenon due to a suppression of antibody formation.4 Recently it has been demonstrated that ACTH or cortisone did not prevent histamine effects on sensitized guine...

PURPOSE The purpose of this study was to evaluate Interferon (IFN)-γ and Interleukin(IL)-17 profiles in patients with different clinical presentations of pulmonary tuberculosis (TB) and to compare them with those of tuberculin-negative and tuberculin-reactive healthy controls METHODS Peripheral blood mononuclear cells (PBMCss), isolated from patients (n=52) and controls (n=30), were stimulate...

Whether the reader is or is not in accord with some of the theoretical parts of the book matters not, the point being that there is here placed within the reach of all who wish to use tuberculin a text-book, written in the simplest and most lucid manner, which will enable them with a little care and practice to select the right case and the right tuberculin and to regular the dosage on fixed pr...