Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy (TMA) which pathophysiology mainly relies on a severe deficiency (either acquired or inherited) of ADAMTS13, the specific von Willebrand factor (VWF) protease. TTP is characterized by a feminine predominance and pregnancy is a precipitating factor for TTP boots. Obstetrical TTP represents at least 20% of all TTP occurring...

Future electronic systems for the implementation of safety-critical applications on-board automotive vehicles will be based on distributed embedded systems. The most critical component in such systems is the communication network that connects the individual electronic modules. For reasons of costs, composability, ease of validation, and certiication the use of time-triggered communication prot...

This paper examines the Time Triggered Protocol (TTP), for the support of distributed real-time systems which has recently emerged from research into the commercial world, and TTP/C, a variant of TTP for safety-critical systems that is coming into use in the automotive industry. The culmination of more than 20 years of effort, TTP has been the focus of more than 100 masters level theses and 25 ...

The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring TTP's significance during fetal development. TTP an...

The transcription factor E2F1 is active during G1 to S transition and is involved in the cell cycle and progression. A recent study reported that increased E2F1 is associated with DNA damage and tumor development in several tissues using transgenic models. Here, we show that E2F1 expression is regulated by tristetraprolin (TTP) in prostate cancer. Overexpression of TTP decreased the stability o...

As the amount of data generated in various distributed environments is rapidly increasing, cloud servers and computing technologies are attracting considerable attention. However, server has privacy issues, including personal information requires help a Trusted Third Party (TTP) for sharing. because value increases, owner who produces must become subject In this study, we use key aggregate sear...

BACKGROUND Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) has been described as a specific sequela of allogeneic HPC transplantation (HPCT). Nevertheless, because multiple transplant-related sequela can cause the characteristic clinical features of TTP-HUS, the diagnosis is difficult. STUDY DESIGN AND METHODS All English-language articles describing patients with TTP-...

BACKGROUND Pregnant women with a history of acquired thrombotic thrombocytopenic purpura (TTP) are considered at risk for disease recurrence and might be at risk for miscarriage, similar to other autoimmune disorders. However, the exact entity of these risks and their causes are unknown. The aim of this study was to evaluate risk factors associated with adverse pregnancy outcome, in terms of bo...

BACKGROUND Accurate estimates of the incidence of thrombotic thrombocytopenic purpura (TTP) are important to assess the resources required for current treatments as well as to anticipate the need to develop new treatments. Previous estimates have been indirect and have not reported data on patients with ADAMTS-13 deficiency. OBJECTIVE To determine the incidence of patients with TTP-hemolytic ...