A series of novel pyrrolo[2,3-d]pyrimidine derivatives was designed and synthesized as thymidylate synthase (TS) inhibitors. Molecular design was performed on the human TS complex model built on the basis of the reported structure of TS-deoxyuridinemonophosphate (dUMP)-CB3717 ternary complex. From a docking study, we expected that a one-carbon bridge between pyrrolo[2,3-d]pyrimidine and an arom...

The Gaussian-2 computational method has been applied to study the following two reactions: (1) dihydrogen exchange between methanol and formaldehyde, and (2) hydrogen transfer in formic acid. In the investigation of these two reactions, the cases of both having and not having a catalytic water molecule have been examined. It has been found that, for the first reaction, the transition structures...

This is the first report on the asymmetric transfer hydrogenation (ATH) of dibenzo[b,f][1,4]oxazepine compounds in the presence of an (R,R)-Ru-Ts-DPEN complex. The developed catalytic asymmetric protocol provides biologically active 11-substituted-10,11-dihydrodibenzo[b,f][1,4]oxazepines with excellent conversion (up to >99%) and high enantioselectivity (up to 93% ee) in water as an environment...

This paper proposes an adaptive TS recurrent fuzzy CMAC (TS-RFCMAC) model based control of uncertain time-delay nonlinear systems. First, we introduce a TS-RFCMAC network and its application on system modeling. Next, a TS-RFCMAC controller is developed based on parallel distributed compensation and adaptive control laws. Even if uncertain local subsystem matrices and fuzzy sets exist in the mod...

The past 5 years have seen a paradigm shift in the survival of patients with advanced melanoma, owed in large part to an improved understanding of the genomic complexity of the disease and the development of novel therapies. Large international efforts to systematically sequence tumours have uncovered molecularly discrete subtypes of melanoma, with mutational characteristics found to segregate ...