Trypanosoma evansi contains protein kinases capable of phosphorylating endogenous substrates with apparent molecular masses in the range between 20 and 205 kDa. The major phosphopolypeptide band, pp55, was predominantly localized in the particulate fraction. Anti-alpha and anti-beta tubulin monoclonal antibodies recognized pp55 by Western blot analyses, suggesting that this band corresponds to ...

Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of these compounds were additionally carried out. Goats demonstrated no signs of acute toxicity, when treated with four doses of 1 mg/kg/day (total dose 4 mg/kg). Complete curative efficacy of experiment...

A natural case of co-infection by Leishmania and Trypanosoma is reported in a dog (Canis familiaris) in south- western state of Mato Grosso do Sul, Brazil. Both amastigote and trypomastigote forms were observed after Giemsa staining of cytological preparations of the dog's bone marrow aspirate. No parasite was detected using medium culture inoculation of the sample. DNA obtained from the bone m...

TTrypanosoma evansi, is one among several species of Trypanosomes responsible for a major protozoan parasitic disease domestic animals. The current study aimed to investigate the trypanocidal effects aqueous and methanolic leaf extracts Balanites aegyptiacaDel (Zygophyllaceae) suramin on albino rats infected with Trypanosoma evansi. In total, 35 Swiss randomly separated into seven (7) groups (A...

This study was conducted to investigate the occurrence of oxidative stress in the heart tissue of rats infected with Trypanosoma evansi. Rats were divided into 2 groups (A and B) with 12 animals each, and further subdivided into 4 subgroups (A1 and A2, 6 animals/each; and B1 and B2, 6 animals/each). Animals in the groups B1 and B2 were subcutaneously inoculated with T. evansi. Thiobarbituric ac...

Human trypanosomiasis is endemic in Africa and South America. Human African Trypanosomiasis (HAT) also known as sleeping sickness is caused by Trypanosoma brucei rhodesiense (in East and South Africa) or Trypanosoma brucei gambiense (in West and Central Africa)1. Disease due to T.b. rhodesiense progresses rapidly over weeks while disease due to T.b. gambiense tends to be chronic. In both the ca...