Introduction Cognitive impairments, the main determinants of functional outcomes in schizophrenia, had limited treatment responses and need a better understanding mechanisms. Dysfunctions dopamine system N-methyl-D-aspartate receptor (NMDAR), primary pathophysiologies may impair cognition. Objectives This study explored effects interactions striatal transporter (DAT) plasma NMDAR-related amino ...

OBJECTIVE With respect to the equivocal value of the reverse perfusion pattern (RPP) in technetium-99m (Tc)-sestamibi myocardial perfusion imaging, a study was carried out to evaluate this pattern in association with the presence or absence of coronary artery disease (CAD) and other underlying factors, mainly the time of acquisition and the presence of intense visceral uptake. PATIENTS AND ME...

This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical NaTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, NaTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage...

Leukocytes labeled with technetium-99m using pretinning with stannous complexes of pyrophosphate, glucoheptonate, and gentisic acid were compared with respect to labeling efficiency, time required for labeling, in vitro cell viability, initial lung transit, and image quality following reinjection into normal volunteers. Gentisic acid pretinning was the best method, offering the shortest prepara...

The recent development of the instantaneously sensing Anger scintillation camera, capable of recording wide-field radioisotope images from the precordium, and a system for video storage and analysis has provided a means of visualizing the anatomic and hemodynamic features of the heart and great vessels without the hazards involved in introducing a radiopaque agent. Sodium pertechnetate (ODmTc04...

The dual radionuclide myocardial distributions of imaging agents potassium43 (49K) and technetium-99m stannous pyrophosphate ('9mTc-PYP) were studied in a 24-hour closed chest canine infarct preparation. In multiple myocardial biopsies in 20 dogs, tissue levels of both radionuclides were compared to either an index of tissue viability (myocardial creatine phosphokinase [CPK] depletion), or to e...

Several radionuclides in a variety of chemical forms have been used for spleen scanning (1). None of these has as desirable physical properties as tech netium-99m, namely, the clean 140 keV gamma, absence of particulate radiation, and short physical half-life (2). As a result, it would be desirable to find a com pound of “9―Tc that could be used for spleen scanning. Technetium-99m sulfur co...

To study the scintigraphic detectability of cardiac rejection, we performed 135 planar myocardial scans ([99mTc]pyrophosphate, 85; 201Tl, 36; 67Ga, 14) together with endomyocardial biopsies in ten patients for a (mean) 17-mo postoperative period. Specificity of each agent exceeded 89%. Technetium-99m pyrophosphate showed results that significantly correlated with the severity of rejection (p = ...