actively proliferating. When the cell growth in vivo becomes stationary, sialic acid is added to the galactose on the nonreducing end (17). The antigen molecule was extracted from MM2 cells by hypotonic incubation and was partially purified by sucrose density gradient centrifugation (18). The humoral factor has a specific binding affinity mainly to the saccharide moiety of the antigen molecule....

al., 2002). Cytotoxicity caused by ROS is mediated in part by the JNK pathway (Matsuzawa et al., 2002). Acti-During inflammation, NF-␬B transcription factors an-vation of this pathway by TNF␣ promotes death by in-tagonize apoptosis induced by tumor necrosis factor ducing cleavage of the Bcl-2 family BH3-only protein, (TNF)␣. This antiapoptotic activity of NF-␬B involves Bid, into jBid, which ta...

In this paper, we present an inference mechanism called the integrated parsing engine which provides a uniform abductive inference mech-anism for natu~al language understmlding. It can (1) make phmsibh, assmnptiox~s, (2) rea~. son with mlfltiple alternatives, (3) switch the search process to the maximally plausible alter.., native, (4) detect contradict ion attd tame COlt -~ clutions which depe...

I start with two rough models of political theory (or philosophy: the dis tinction is not important here) with respect to the relation of morality to political practice. One is an enactment model. The model is that political theory formulates principles, concepts, ideals, and values; and politics (so far as it does what the theory wants) seeks to express these in political action, through persu...

actively proliferating. When the cell growth in vivo becomes stationary, sialic acid is added to the galactose on the nonreducing end (17). The antigen molecule was extracted from MM2 cells by hypotonic incubation and was partially purified by sucrose density gradient centrifugation (18). The humoral factor has a specific binding affinity mainly to the saccharide moiety of the antigen molecule....

tors by the specific names used in their original descriptions. These receptors are generally large (90–130 kDa) Philadelphia, Pennsylvania 19104-6148 acidic proteins sharing 15%–25% sequence identity within a given organism. They all have an N-terminal RanGTP-binding domain, a C-terminal cargo-binding Eukaryotic cells are equipped with a machinery charged domain, and the capacity to bind compo...

Although our knowledge of the check mechanism of the horizontal muscles is fairly well established, very little positive evidence is available as to the check mech­ anism associated with the vertical muscles. This is understandable when one considers the greater complexity in the anatomic ar­ rangement of the vertical muscles as com­ pared with the horizontal muscles. With the hope of obtaining...

Key words: cyclosporin; haemolytic uraemic syndrome; day 2 was discontinued the same day, as laboratory studies revealed a Coombs-negative microangiopathic renal transplantation; thrombotic microangiopathy haemolytic anaemia (MAHA) with thrombopenia: haemoglobin decreased to 6.8 from 8.5 g/dl (D1), lactate dehydrogenase (LDH) increased to 987 from Introduction 140 IU/l (D1), very low haptoglobi...

The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mech anism involving free radicals and active oxygen species. Fur thermore, the ability of the compound to bind to DNA appeared to enhance its cytocidal activity. The same model compounds were used to investigate the effect of the quinone group on cellular DNA. DNA single-strand b...

complex: the low intrinsic protease activity of the pro-caspase is then sufficient to trigger intermolecular cleav-age and subsequent activation. Formation of such pro-44 Lincoln's Inn Fields London WC2A 3PX caspase complexes is mediated by the prodomains of the apical caspases that interact with adaptor molecules United Kingdom to form the " apoptosome. " The adaptor molecules serve as protein...