oxidative stress plays a major role in the pathogenesis of alzheimer's disease (ad) of sporadic origin. the expression of dhcr24 (seladin-1), marker for neuronal oxidative stress and degeneration, has been reported to be altered in the brains of ad patients. in the present study, we investigated the effect of trimetazidine (tmz) on the hippocampal oxidative parameters and the expression of dhcr...

Although the management of ischemic heart disease and chronic heart failure (CHF) has made considerable progress over the past years, CHF is still a tremendous medical burden. The metabolic and therapeutic approach might play a significant role in reducing disease progression and mortality rate. The metabolic modulator trimetazidine, a partial inhibitor of long chain 3-ketoacyl CoA thiolase act...

Primary heart failure in cardiomyopathy occurs in (1) hypertrophic cardiomyopathy, a genetic disease of the sarcomere; and (2) in dilated cardiomyopathy. The latter is often regarded as idiopathic in origin, but requires exclusion of all possible etiologies which are becoming easier to identify with modern investigative techniques. Tachycardia-induced cardiomyopathy is now increasingly recogniz...

OBJECTIVE To evaluate the effects of bisoprolol combined with trimetazidine on the treatment of heart failure patients having concomitant chronic obstructive pulmonary disease (COPD); in comparison with control group treated with standard therapy only. METHODS A total of 120 heart failure patients having concomitant COPD were selected and randomly divided into a control group and a treatment ...

Aim. The present work aimed at studying the proatherogenic potential of doxorubicin-cyclophosphamide (AC) chemotherapy regimen while simultaneously substantiating use trimetazidine as a modifier changes induced. Material and Methods. fundamental, randomized, controlled, experimental in vivo study was conducted. To perform work, 80 inbred Wistar rats were randomly divided into four groups with e...

The hypothesis proposed is that heart failure (HF) is associated with a reactive hyperadrenergic state that increases circulating plasma free fatty acids (FFAs), which leads to impaired glucose metabolism and insulin resistance. We propose that increased FFA-induced mitochondrial uncoupling and substantial oxygen wastage is closely associated with the generation of reactive oxygen species, infl...

BACKGROUND Metabolism remodeling has been recognized as an early event following cardiac pressure overload. However, its temporal association with ventricular hypertrophy has not been confirmed. Moreover, whether trimetazidine could favorably affect this process also needs to be determined. The aim of the study was to explore the temporal changes of myocardial metabolism remodeling following pr...

KURALAY, F., ALTEKIN, E., YAZLAR, A.S., ONVURAL, B. and GOLDELI, O. Suppression of Angioplasty-Related Inflammation by Pre-Procedural Treatment with Trimetazidine. Tohoku J. Exp. Med., 2006, 208 (3), 203-212 ── Percutaneous transluminal coronary angioplasty (PTCA) has been recognized as a reliable treatment procedure for acute reversible ischemia and reperfusion. Ischemic reperfusion cycle in P...