OBJECTIVE Reduced lopinavir concentrations have been demonstrated with use of the capsule formulation during the third trimester of pregnancy. This study determined lopinavir exposure with an increased dose of the new tablet formulation during the third trimester. DESIGN International Maternal Pediatric Adolescent AIDS Clinical Trials 1026s is a prospective nonblinded pharmacokinetic study in...

OBJECTIVE The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants. METHODS We analyzed maternal urinary levels of nephrin in women ...

OBJECTIVE To estimate the value of first or second trimester placental growth factor (PlGF) as an additional antenatal screening marker for Down syndrome. DESIGN Nested case-control study. SETTING Antenatal screening service. POPULATION OR SAMPLE 532 Down syndrome pregnancies and 1,155 matched unaffected pregnancies. METHODS Stored maternal serum samples (-40°C) were assayed for PlGF. M...

INTRODUCTION Performing a myomectomy during pregnancy is extremely rare due to the risk of pregnancy loss, hemorrhage and hysterectomy. Favorable outcomes have been demonstrated with select second trimester gravid myomectomies. Literature documenting first trimester surgical management of myomas during pregnancy is scant. Patients with symptomatic myomas failing conservative management in the f...

The National Institute of Child Health and Human Development (NICHD), the Society for Maternal-Fetal Medicine, and the American College of Obstetricians and Gynecologists (ACOG), cosponsored a workshop on December 16-17, 2004, to discuss the evidence for first-trimester Down syndrome screening and to explore the effects of combining first- and second-trimester screening, given the results of re...

The current study was designed to investigate the changes of liver enzymes during normal pregnancy. To achieve the intended aim, 185 pregnant women of aged 20 – 37 years(60 women in first trimester, 65 women in second trimester and 60 women in third trimester of pregnancy), also the study contain70 women(control individuals) in age near to age of pregnant women. The levels of Alanine amino tran...

BACKGROUND Establishment of trimester- and assay-specific reference intervals for every population is recommended. The aim of this study was to establish a trimester- and assay-specific reference interval for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in Korean pregnant women. METHODS From April 2012 to December 2012, 531 pregnant women receiving prenatal care and 238 age-matc...

The microvillous membrane (MVM) potential ( E m) of first trimester human placental villi was measured and compared with that in villi from term human placentas. The median E m in first trimester villi (-28 mV) was significantly more negative than that at term (-21 mV; P < 0.001). The median E m measured in villi from early ( weeks 6-11) first trimester (-32 mV) was significantly more negative ...

OBJECTIVE To investigate the association between weekly weight gain, during the second and third trimesters, classified according to the 2009 Institute of Medicine (IOM/NRC) recommendations, and maternal and fetal outcomes. METHODS Gestational weight gain was evaluated in 2,244 pregnant women of the Brazilian Study of Gestational Diabetes (Estudo Brasileiro do Diabetes Gestacional--EBDG). Out...

Disturbances in decidual and placental vascular development may play a role in the pathogenesis of pregnancy complications. This study focused on the role of angiogenic factors in the first trimester in the pathogenesis of preeclampsia (PE) and/or fetal growth restriction (FGR). First-trimester decidua was obtained during chorionic villous sampling.The expression of the angiogenic factors was d...