The neurobiological model of depressive disorder may be correlated with the animal model on rat, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, the increase of cortisol level being specific to the model of depression in women. The neurobiological model of depression in women presents vulnerabilities for some cerebral structures (hippocampus, frontal cortex, cerebral amygdala). ...

BACKGROUND Treatment of negative symptoms in chronic schizophrenia continues to be a major clinical issue. AIMS To analyse the efficacy of add-on antidepressants for the treatment of negative symptoms of chronic schizophrenia. METHOD Systematic review and meta-analysis of randomised controlled trials comparing the effect of antidepressants and placebo on the negative symptoms of chronic sch...

The effects of m-chlorophenylpiperazine (m-CPP) (0.5 mg/kg) on sleep architecture and behavior were examined in six healthy volunteers following a single oral dose of the drug in a randomized, double-blind, placebo-controlled study. m-CPP reduced total sleep time (TST) and sleep efficiency in all subjects. Slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep were decreased and stage 1 sleep...

A 79-year-old woman in the course of a syncope evaluation is shown to have a trazodone-related cardiac arrhythmia confirmed by drug rechallenge. This nontricyclic antidepressant should be considered as potentially arrhythmogenic despite its generally favorable cardiovascular profile.

Currently, the interest of veterinarians and owners in pharmacological correction situational behavioral disorders companion animals has increased significantly. To quickly correct deviant behavior dogs cats, use some psychotropic drugs used humane medicine, particular, trazodone, an antidepressant antagonist / serotonin reuptake inhibitor.
 
 Based on analysis literature sources, dat...

Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting w...