A traumatic brain injury (TBI) is an that disrupts the normal function, and caused by a bump, blow, or jolt to head penetrating injury. TBI range from mild concussions, without loss of consciousness, severe TBI, which can result in deep coma death. Types TBI's patients sustain include hematomas, CTE. The length time have symptoms depends on severity, with lasting few days even rest patient’s li...

Traumatic brain injury (TBI) is a significant source of morbidity and mortality in the adult population. The management of traumatic brain injury depends on its severity. It must be recognized that almost all forms of treatment for TBI are geared towards the minimization of secondary injury, as it is assumed that primary injury is irreversible. The discussion here represents much of what is kno...

Objective(s): Neuroprotection is created following the inhibition of angiotensin II type 1 receptor (AT1R). Therefore, the purpose of this research was examining AT1R blockage by candesartan in diffuse traumatic brain injury (TBI). Materials and Methods: Male rats were assigned into sham, TBI, vehicle, and candesartan groups. Candesartan (0.3 mg/kg) or vehicle was administered IP, 30 min post-T...

Background: Approximately two percent of Finns have sequels after traumatic brain injury (TBI), and many TBI patients are young or middle-aged. The high rate of unemployment after TBI has major economic consequences for society, and traumatic brain injury often has remarkable personal consequences, as well. Structural imaging is often needed to support the clinical TBI diagnosis. Accurate early...

Objective(s) Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton,s jelly stem cell) with bone marrow cell mobilized by granulocytecolony stimulating factor (G-CSF) in rats injured with cortical com...

Traumatic brain injury (TBI) is a major medical and socio-economic problem, and is the leading cause of death in children and young adults. The critical care management of severe TBI is largely derived from the "Guidelines for the Management of Severe Traumatic Brain Injury" that have been published by the Brain Trauma Foundation. The main objectives are prevention and treatment of intracranial...

the sex hormone progesterone has been shown to improve outcomes in animal models and two early-phase trials involving patients with traumatic brain injury (tbi). the aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with diffuse and acute tbi. a prospective, randomized, double-blind trial of progesterone was conducted in our...

background traumatic brain injury (tbi) is an important public health problem throughout the world. objective this study assesses repeated glasgow coma scale (gcs) scores to predict the severity of tbi and survival of the patients. materials and methods a sample of 239 patients who were hospitalized with traumatic brain injury was selected by random sampling from icu wards at shahid beheshti ho...

OBJECTIVE To determine effectiveness of communication training for partners of people with severe traumatic brain injury. DESIGN Three arm non-randomized controlled trial comparing communication partner training (JOINT) with individual treatment (TBI SOLO) and a waitlist control group with 6 month follow-up. PARTICIPANTS Forty-four outpatients with severe chronic traumatic brain injuries we...

traumatic brain injury (tbi) is a global health concern that typically causes emotional disturbances and cognitive dysfunction. it elicits a complex secondary injury response, with neuroinflammation as a crucial central component. secondary pathologies following tbi may be associated with chronic neurodegenerative disorders and an enhanced likelihood of developing dementia-like disease in later...