*Please consult the online schedule for this course for the definitive date and time for this lecture. Key Concepts vs Supplementary Information: The syllabus is meant to accompany the lectures and the material covered (other) than that in italics) is considered important to your understanding of the subject. Key items are marked in bold. Supplemental information is marked in italics. Lecture O...

A trait is often of interest by virtue of being either highly desirable, for example intelligence, or highly undesirable, for example cancer. Genetic influence over the trait can be established inmanyways including twin studies, clustering statistics and statistical modelling. Once the existence of a genetic component has been established, the next step is to locate the genes involved. The ease...

microRNAs (miRNAs) are a class of small RNAs (19-25 nucleotides in length) processed from double-stranded hairpin precursors. They negatively regulate gene expression in animals, by binding, with imperfect base pairing, to target sites in messenger RNAs (usually in 3' untranslated regions) thereby either reducing translational efficiency or determining transcript degradation. Considering that e...

1Center for Experimental Medicine and Department of Neurology, TheThird Xiangya Hospital, Central South University, Changsha 410013, China 2Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, 97080 Wurzburg, Germany 3Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School o...

Selecting cattle most resistant to the development of infectious diseases will decrease costs of production and should therefore be included in the overall breeding objective. Such selection goals may include resistance to infection with a pathogen (absence of susceptibility), resistance to disease (no-development of disease), tolerance (capability of untreated individuals to maintain a reasona...

The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...