Most organic acidemias become clinically apparent during neonatal period or early infancy. Infants typically have severe metabolic acidosis with increased anion gap, ketosis and hyperammonemia. Extremely high ammonia levels exceeding 1000 μmol/L is a discriminative feature for urea cycle defect while levels exceeding 200-300 μmol/L are rarely encountered in other reasons of hyperammonemia. Leth...

TOPIC: Critical Care TYPE: Fellow Case Reports INTRODUCTION: In the US prevalence of obesity has risen to 39.8% and affected about 93.3 million adults in 2015. Morbidly obese patients are increasingly pursuing bariatric surgery. While benefits surgery numerous, it is important recognize understand short term long postoperative complications. Hyperammonemic syndrome an uncommon but severe compli...

Background. Hyperammonemia resulting from chronic liver disease (CLD) can potentially challenge and damage any organ system of the body, particularly the brain. However, there is still some controversy regarding the diagnostic or prognostic values of serum ammonia in patients with over hepatic encephalopathy, especially in the setting of acute-on-chronic or chronic liver failure. Moreover, the ...

cases with hirschsprung’s disease show the functional intestinal obstruction. obstruction in these patients may lead to bacterial overgrowth with stasis and inflammation of the colon. bacterial overgrowth can cause hyperammonemia that makes lethargy and loss of conscious and finally admitting in icu. the purpose of this case report is to present a case that had hirschsprung’s disease and referr...

UNLABELLED BACKGROUND Exercise is an excellent tool to study the interactions between metabolic stress and the immune system. Specifically, high-intensity exercises both produce transient hyperammonemia and influence the distribution of white blood cells. Carbohydrates and glutamine and arginine supplementation were previously shown to effectively modulate ammonia levels during exercise. In ...

The cerebral tricarboxylic acid (TCA) cycle rate and the rate of glutamine synthesis were measured in rats in vivo under normal physiological and hyperammonemic conditions using 13C NMR spectroscopy. In the hyperammonemic animals, blood ammonia levels were raised from control values of approximately 0.05 mM to approximately 0.35 mM by an intravenous ammonium acetate infusion. Once a steady-stat...

this report details the presence of hyperammonemia in a patient who sustained cardiac arrest after a traumatic amputation. serum ammonia levels may rise due to numerous etiologies; however, few reports detail its usefulness in diagnosing subclinical seizures. in this case, we successfully utilized persistently elevated serum ammonia levels as a marker of subclinical seizures in a patient who su...

Epidemiological data suggests that approximately 10-65% of patients with mild to moderate COVID-19 have persistent symptoms already after an acute infection, which may last for six months or more. Previous clinical studies shown similar also occur in the liver. Russian scientists studied phenomenon hyperammonemia phase COVID-19, but problem elevated blood ammonia levels post - COVID syndrome ha...