Purpose: To develop transdermal patches of meloxicam (MLX) using chitosan and hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) as hydrophilic polymers, polyamido amine (PAMAM) dendrimer as a permeation enhancer, and dibutyl pthalate as a plasticizer Methods: The patches were prepared by solvent casting evaporation technique using 3-factor, 3-level Box-Behnken design. The patches...

Skin constitutes an excellent barrier for the transdermal delivery of hydrophilic or high molecular weight drugs. Low efficacy demonstrated in clinical trials for some topical drugs is mainly due to low skin penetration ability related to the efficient barrier properties of stratum corneum (SC). Transdermal delivery of molecules in the skin is limited by the full epidermis, not just stratum cor...

Skin constitutes an excellent barrier for the transdermal delivery of hydrophilic or high molecular weight drugs. Low efficacy demonstrated in clinical trials for some topical drugs is mainly due to low skin penetration ability related to the efficient barrier properties of stratum corneum (SC). Transdermal delivery of molecules in the skin is limited by the full epidermis, not just stratum cor...

Narcotics are frequently prescribed to alleviate pain in patients with serious medical illnesses such as cancer. Because of their nonoral route of administration, fentanyl patches are now being frequently prescribed. However, the widespread use of fentanyl patches has been associated with medication errors and misuse [Butts and Jatoi: J Opioid Manag 2011;7:35-45]. The transdermal delivery of fe...

Objective: The present study was an attempt to develop alternative dosage form for the existing conventional oral, parenteral proton pump inhibitor (PPI) as transdermal patches treating peptic ulcers. Methods: Transdermal of PPI were prepared using HPMC E5 with PVP K 30 and Eudragit L100 polymers in different ratios by a solvent evaporation method. All formulated subjected various evaluation pa...

OBJECTIVE To deliver 2,3,5,6-tetramethylpyrazine (TMP) in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. METHODS The pseudo-ternary phase diagram for microemulsion regions was constructed using isopropyl myristate as oil phase, Labrasol(®) as surfactant, and Plurol(®) Oleique CC 497 as cosurfactant. A...