Currently a growing interest to improve the pharmacological therapy exists, not only by the production and the appearance of new drugs, but guaranteeing that the uses of those which already exist, become more effective. In fact, the conventional pharmaceutical formulations of different drugs present a few secondary effects due to oral administration. In order to avoid these undesired side effec...

BACKGROUND To assess the role of transdermal opioids as a front-line approach to moderate to severe cancer pain. METHODS A systematic review of the literature was performed by two authors. An analysis of the level of evidence and risk/benefit ratio was performed for all of the selected trials. A combined analysis of the included studies to assess the level of evidence, risk/benefit ratio and ...

the application of low-frequency ultrasound for transdermal delivery of insulin is of particular public interest due to the increasing problem of diabetes. the purpose of this research was to develop an air ultrasonic ceramic transducer for transdermal insulin delivery and evaluate the possibility of applying a new portable and low-cost device for transdermal insulin delivery. twenty-four rats ...

The transdermal application of drugs has attracted increasing interest over the last decade or so, due to the advantages it offers, compared to other delivery methods. The development of an efficient means of transdermal delivery can increase drug concentrations, while reducing their systemic distribution, thereby avoiding certain limitations of oral administration. The efficient barrier functi...

Brucine is the active component in traditional Chinese medicine "Ma-Qian-Zi" (Strychnos nux-vomica Linn), with capabilities of analgesic, anti-inflammatory, anti-tumor and so on. It is crucial how to break through the impact of cuticle skin which reduces the penetration of drugs to improve drug transmission rate. The aim of this study is to improve the local drug concentration by using ultrasou...

Objectives: The objective of this study is to extract Phytochemical constituent from Cinnamon Bark and design develop the transdermal patch herbal drug along with modern medicine Glibenclamide using solvent casting method reduce dose required obtain same pharmacological effect, also toxicity drug. Methods: Transdermal patches were formulated by method. physical chemical similarity medication ba...

barrier to the permeation of most drugs, and especially as a hydrophobic barrier against hydrophilic drugs and ionized drugs. One possible means of facilitating the transdermal delivery of ionic drugs is through ion-pair formation. Oppositely charged ions can interact to form new species known as ion-pairs. This association reduces or neutralizes electrostatic charges and consequently reduces t...

BACKGROUND AND THE PURPOSE OF THE STUDY Domperidone (DOM) is a dopamine- receptor (D(2)) antagonist, which is widely used in the treatment of motion-sickness. The pharmacokinetic parameters make DOM a suitable candidate for transdermal delivery. The purpose of the present investigation was to develop transdermal delivery systems for DOM and to evaluate their physicochemical characteristics, in ...

cally as it 1) has a rapid onset and cessation of effect upon intravenous infusion, 2) accumulates little and induces a brief but profound anesthesia, 3) maintains a level in the circulation similar to the levels achieved by inhalation anesthetics. Since PF is formulated as an intravenous emulsion containing soybean oil and egg yolk lecithin, it causes problems of pain at the site of injection ...