Multiple RNA polymerase II (RNAPII) molecules can transcribe a gene simultaneously, but what happens when such polymerases collide--for example due to polymerase pausing or DNA damage? Here, RNAPII collision was characterized using a reconstituted system for simultaneous transcription by two polymerases. When progression of leading polymerase is obstructed, rear-end collision entails a transien...

We evaluated the activity of fluconazole and voriconazole against 83 Candida albicans isolates from patients with haematological malignancies, comparing the NCCLS microdilution method (M27-A) with a modified method with RPMI-2% glucose and MIC endpoint at 50% inhibition. Both drugs were highly active regardless of the year, the site of isolation of the strain and the test method employed. In se...

This study presents a dynamic-induced direct-shear model to investigate the dynamic triggering of frictional slip on simulated granular gouges. An incident P-wave is generated as a shear load and a normal stress is constantly applied on the gouge layer. The shear stress accumulates in the incident stage and the frictional slip occurs in the slip stage without the effect of the reflected wave. T...

An Analysis of the Basketball Endgame: 
 When to Foul When Trailing and Leading ! Franklin H. J. Kenter Rice University Houston, TX, U.S.A., 77005 Email: [email protected] !! Abstract ! A common tactic near the end of a basketball game is for the trailing team to foul in order to gain an advantage by forcing the opponent to shoot free throws. While this tactic is widely used at almost ...

High intensity acoustic radiation occurs when turbulence convects past airframe trailing edges. A mathematical model is developed to predict this acoustic radiation. The model is dependent on the local flow and turbulent statistics above the trailing edge of the flight vehicle airframe. These quantities are dependent on the jet and flight vehicle Mach numbers and jet temperature. A term in the ...

This paper concerns a numerical study of employing an adaptive trailing edge flap to control the lift of an airfoil subject to unsteady inflow conditions. The periodically varying inflow is generated by two oscillating airfoils, which are located upstream of the controlled airfoil. To establish the control system, a standard PID controller is implemented in a finite volume based incompressible ...

This study analyzes signaling events initiated through binding of the leukocyte integrin LFA-1 to ICAM-1, which leads to T cell attachment, polarization and random migration. These events are critically dependent on dynamic changes in the acto-myosin cytoskeleton under the regulation of myosin light chain kinase and ROCK (Rho kinase). A key finding is that the activity of these two kinases is s...