PURPOSE This article reviews the most important muscle toxins, many of which are widely prescribed medications. Particular emphasis is placed on statins, which cause muscle symptoms in a relatively large proportion of the patients who take them. RECENT FINDINGS As with other toxic myopathies, most cases of statin-associated myotoxicity are self-limited and subside with discontinuation of the ...

By ARIF I. CETINGIL AND MUHLIS A. OZEN T HE EXCESSIVE porphyrin excretion seen in idiopathic disturbances of porphyrin metabolism must be differentiated from the porphyrinuria that occurs in various diseases associated with alterations in porphyrin metabolism. Porphyrinuria can he observed in the course of various diseases and may result from the intake of various drugs and poisons. It is well ...

In This Issue In This Issue Toxic apoptosis antel et al. report that ␣-toxin from Staphylococcus aureus can induce apoptosis in immune cells (page 637). This may help the bacterium to immunosuppress the victim and continue proliferating. S. aureus was known to induce apoptosis, but the underlying mechanism was unknown. Bantel et al. find that the inducer is soluble. B Apoptosis can be triggered...

In Transactional Memory workloads, conflicts among transactions necessitate that some transactions either block, or else abort. The more common approach, aborting, is under-studied. Much effort has explored the use of schedulers and gatekeepers when the global abort rate is high. Handling short spikes in the abort rate, especially due to a single transaction with a high likelihood of conflict, ...

principal investigator for the team. His collaborators were Jean-Pierre Kinet, a professor of pathology at Harvard Medical School who first cloned the gene for the IgE receptor in 1986, and Scott Garman, a postdoctoral fellow in the Northwestern Department of Biochemistry, Molecular Biology, and Cell Biology. About 50 million people in the United States have some form of allergy. Many allergies...