Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...

Breast cancer, as a heterogeneous disease, includes a wide range of pathological and clinical behaviors. Current treatment protocols, including radiotherapy, chemotherapy, and hormone replacement therapy, are mainly associated with poor response and high rate of recurrence. Therefore, more efforts are needed to develop alternative therapies for this type of cancer. Immunotherapy, as a novel str...

allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with ige-mediated conditions until a dose is reached that is effective in reducing disease severity from natural exposure. in the present study we evaluated a period of six years immunotherapy allergic rhinitis and allergic asthma patients with positive skin prick test of comm...

The main objective of this study is to analyze the effects sublingual specific immunotherapy and conventional drug therapy on inflammatory factors immune function in children with allergic rhinitis. research subjects were divided into three groups, group A received administration dust mite drops, B routine treatment such as passive intervention topical hormones, antihistamines nasal irrigation ...

Transdermal drug delivery exhibited encouraging prospects, especially through superficial administration routes. However, only a few limited lipophilic molecules could cross the skin barrier, those are with low molecular weight and rational Log P value. Microneedles (MNs) can overcome these limitations to deliver numerous drugs into dermal layer by piercing outermost of body. In case cancer tre...

brucellosis is an infectious disease and it seems that it affects human immune system and can cause acute, subacute and chronic clinical features. forty patients suffering from chronic brucellosis were studied for cd3+, cd4+,cd8+, cd19+, cells and cd4+/cd8+ ratio by flow cytometry before and after treatment with antibiotics and immunopotentiators. the results were compared with 15 healthy contr...

specific local immunotherapy has been recently introduced as an alternative to classic subcutaneous immunotherapy in treatment of allergic rhinitis. in this study, the effects of sublingual immunotherapy (slit) on symptoms and medication score and skin prick test evaluation of patients with allergic rhinitis were investigated. in this placebo controlled trial, twenty four patients aged 5-18 yea...

Immunotherapy has drastically improved the survival prospect for advanced melanoma. Unfortunately, these treatments often come with cutaneous side effects which may cause patient to discontinue or delay therapy. To understand mechanism of immunotoxicity in relation clinical presentation, we characterized symptom clusters by and histologic morphology, severity rating, transcriptional analyses pa...

Seizure and epilepsy can be related to autoimmune diseases and processes. Accurate diagnosis is essential for better treatment of these conditions. Different clinical studies have been conducted to diagnose and treat autoimmune epilepsy. Rapid treatment of these diseases helps to Improve prognosis and less relapses. Conventional epilepsy treatments including antiepileptic drugs are less success...

niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. the topical form of n-acetyl glucosamine (nag) recently has been considered in the treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. to improve nag penetration into the skin we formulated the drug in niosomes...