The permeation properties of twenty newly synthesized α-alkoxyalkanoyl and α-aryloxyalkanoyl C-21 esters of standard corticosteroids: Fluocinolone acetonide, dexamethasone, triamcinolone acetonide and hydrocortisone were established using a PAMPA assay (70% silicone oil and 30% isopropyl myristate). The data were compared with parent corticosteroids with addition of mometasone furoate and hydro...

We investigated the skin tolerance and anti-inflammatory potential of a nanoparticular solubilisate of a luteolin-rich Reseda extract (s-RE) in two independent studies in vivo. Reseda luteola extract containing 40% flavonoids was solubilized with polysorbate, resulting in product micelles with a diameter of 10 (+/-1.5)nm. Standardized inflammation was induced by irradiating test areas on the ba...

Received for publication October 1, 1962. was found to be highly sensitive to 9-a-fluoro hydrocortisone (9-AFII) (fl). In 1960, a 9-AFH resistant tumor line was developed from the sub cutaneously transferred line of the lymphosarcoma (19). The effects of steroids and fluoropynimidines were studied alone and in combination on the growth of P1798 neoplasms, sensitive and resist ant to 9-AFII:, in...

background: post? and intra?operative  shivering is one of the most complications of spinal anesthesia so recommend a suitable drug with at least complications for prevention and control of postoperative shivering. this current study aimed to compare the preventive effect of  hydrocortisone on intra? and post?operative shivering in patients undergoing surgery with spinal anesthesia. materials a...

A 7-month-old male infant was brought to this department by his parents without referral from his family doctor. For 6 months he had suffered from a rash in the napkin area which was resistant to various treatments. These had included a variety of 'barrier' creams, topical antifungal agents and Hydrocortisone ointment. Recently the parents had become concerned by the development of two lesions ...

adverse reactions of streptokinase in patients with or without hydrocortisone injection nasiri m*1 , rahimian b2, bashiri t 3, salmalian f4 received: 25 april, 2010 accepted: 27 july, 2010 abstract background & aims: streptokinase is one of the most useful drugs in acute myocardial infarction. researches show that timely given injection of streptokinase decreases total mortality. allergic react...

Bacground: Evidence from several lines of investigations suggests that Toll-like receptor 4 (TLR4) is involved in atherosclerosis as a bridge between innate and acquired immunity. Percutaneous coronary intervention (PCI) can trigger inflammation through activation of human TLR4 (hTLR4) on monocytes. Hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of a...

Glucagon alone, given to adrenalectomized rats, caused induction of tyrosine aminotransferase only in repeated doses. A single dose given with or 5 hours after hydrocortisone enhanced 3-fold the induction of tyrosine aminotransferase by the hydrocortisone. Glucagon did not alter the levels of tryptophan oxygenase in these situations. The simultaneous administration of actinomycin D completely i...