نتایج جستجو برای: tnfr1

تعداد نتایج: 1066  

Journal: :Blood 2009
Manfred Kneilling Reinhard Mailhammer Lothar Hültner Tanja Schönberger Kerstin Fuchs Martin Schaller Daniel Bukala Steffen Massberg Christian A Sander Heidi Braumüller Martin Eichner Konrad L Maier Rupert Hallmann Bernd J Pichler Roland Haubner Meinrad Gawaz Klaus Pfeffer Tilo Biedermann Martin Röcken

Signaling through tumor necrosis factor receptor 1 (TNFR1) controls bacterial infections and the induction of inflammatory Th1 cell-mediated autoimmune diseases. By dissecting Th1 cell-mediated delayed-type hypersensitivity responses (DTHRs) into single steps, we localized a central defect to the missing TNFR1 expression by endothelial cells (ECs). Adoptive transfer and mast cell knockin experi...

2016
YANRU DONG CUIFEN BAO JINGWEI YU XIA LIU

In the current study, the activation of tumor necrosis factor-α receptor 1 (TNFR1) and receptor-interacting protein kinase 3 (RIP3) were investigated following cerebral ischemia-reperfusion injury (CIRI). Healthy SD rats were randomly divided into 3 groups: Sham operation group, model group and inhibitor group. The model group and inhibitor group were further divided into 4 subgroups of 6, 12, ...

Journal: :The Journal of clinical investigation 2006
Wulf Schneider-Brachert Vladimir Tchikov Oliver Merkel Marten Jakob Cora Hallas Marie-Luise Kruse Peter Groitl Alexander Lehn Eberhard Hildt Janka Held-Feindt Thomas Dobner Dieter Kabelitz Martin Krönke Stefan Schütze

The adenoviral protein E3-14.7K (14.7K) is an inhibitor of TNF-induced apoptosis, but the molecular mechanism underlying this protective effect has not yet been explained exhaustively. TNF-mediated apoptosis is initiated by ligand-induced recruitment of TNF receptor-associated death domain (TRADD), Fas-associated death domain (FADD), and caspase-8 to the death domain of TNF receptor 1 (TNFR1), ...

2007
Ming-Ou Lu Rui-Sheng Duan Hernan Concha Quezada Zhi-Guo Chen Eilhard Mix Tao Jin Xin Yang Hans-Gustaf Ljunggren Jie Zhu

The role of tumor necrosis factor (TNF)-α and its receptors in the pathogenesis of experimental autoimmune neuritis (EAN) induced by P0 peptide 180–199 in TNFR1 (p55) deficient (TNFR1−/−) mice was investigated. Compared to wild type EAN mice, TNFR1−/− EAN mice developed significantly more severe clinical signs, in parallel with enhanced numbers of inflammatory infiltrating cells in peripheral n...

Journal: :Circulation 2009
Tariq Hamid Yan Gu Roger V Ortines Chhandashri Bhattacharya Guangwu Wang Yu-Ting Xuan Sumanth D Prabhu

BACKGROUND Although preclinical data suggested that tumor necrosis factor-alpha (TNF) neutralization in heart failure (HF) would be beneficial, clinical trials of TNF antagonists were paradoxically negative. We hypothesized that TNF induces opposing inflammatory and remodeling responses in HF that are TNF-receptor (TNFR) specific. METHODS AND RESULTS HF was induced in wild-type (WT), TNFR1(-/...

2014
Jinny Tomar Chiranjib Chakraborty C. George Priya Doss V. K. Gera

Human death receptors (TNFR1, FAS, DR3, DR4, DR5, DR6 and TNFBR), primarily from tumor necrosis receptor super family, play an essential role in the process of the extrinsic pathway of apoptosis. We performed conserved domain, amino acid residues analysis in which cysteine residues were found to be highly conserved for all the family members. Sixteen (16) highly conserved residues were observed...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010
Ilona Idasiak-Piechocka Andrzej Oko Elzbieta Pawliczak Elzbieta Kaczmarek Stanisław Czekalski

BACKGROUND The effects of tumor necrosis factor α (TNF α), a potent proinflammatory cytokine, in the kidneys are mediated by two membrane receptors (TNFR), TNFR1 and TNFR2. The expression of both TNF and TNFRs increases in several kidney diseases and is associated with the shedding of the receptors out of the cell membranes. In an experimental model of glomerulonephritis (GN), elevated concentr...

2012
Ke Wang Gencheng Han Yan Dou Yi Wang Guijun Liu Renxi Wang He Xiao Xinying Li Chunmei Hou Beifen Shen Renfeng Guo Yan Li Yanchun Shi Guojiang Chen

Tumor necrosis factor-α (TNF-α) is a key factor for the pathogenesis of inflammatory bowel diseases (IBD), whose function is known to be mediated by TNF receptor 1 (TNFR1) or 2. However, the precise role of the two receptors in IBD remains poorly understood. Herein, acute colitis was induced by dextran sulfate sodium (DSS) instillation in TNFR1 or 2-/- mice. TNFR1 ablation led to exacerbation o...

Introduction: Recent studies demonstrated that cannabidiol had neuroprotective property. Thereis some evidence about effective role of cannabidiol in reducing ischemic damages. It has been reported that infarct size is influenced by various factors after MCAO, including inflammatory factors. The aim of the present study was to evaluate the effect of cannabidiol on infarction volume and correlat...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005
Rafia S Al-Lamki Jun Wang Peter Vandenabeele J Andrew Bradley Sathia Thiru Dianghong Luo Wang Min Jordan S Pober John R Bradley

In normal kidney, TNFR1 is expressed in glomerular and peritubular capillary EC, and some tubular cells, and colocalizes with inactive apoptosis signal-regulating kinase-1 (ASK1) phosphorylated at serine 967. Biopsies of rejecting or ischemic renal allografts, which show both tubular cell injury and proliferation, display down-regulation of TNFR1 and activation of ASK1 as well as up-regulation ...

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