نتایج جستجو برای: tlr4 gene

تعداد نتایج: 1150600  

2017
Jia Zhu Aihua Tan Ziting Yao Yong Gao Weimin Xie Yongkui Lu Zengnan Mo

Toll-like receptors 4, 5 and 9 (TLR4, 5 and 9) are involved in the induction of innate immune response against hepatitis B virus (HBV) infection. This study aimed to explore the potential role of TLR4, 5 and 9 polymorphisms in the susceptibility to HBV clearance and HBV-related hepatocellular carcinoma (HCC). In this study, five single nucleotide polymorphisms (SNPs) (rs1927911, rs11536889, rs1...

Journal: :Human molecular genetics 2005
Sepideh Zareparsi Monika Buraczynska Kari E H Branham Sapna Shah Donna Eng Mingyao Li Hemant Pawar Beverly M Yashar Sayoko E Moroi Paul R Lichter Howard R Petty Julia E Richards Gonçalo R Abecasis Victor M Elner Anand Swaroop

Age-related macular degeneration (AMD) is a genetically heterogeneous disease that leads to progressive and irreversible vision loss among the elderly. Inflammation, oxidative damage, cholesterol metabolism and/or impaired function of retinal pigment epithelium (RPE) have been implicated in AMD pathogenesis. We examined toll-like receptor 4 (TLR4) as a candidate gene for AMD susceptibility beca...

2016
Ashish Bhaladhare Deepak Sharma Amit Kumar Arvind Sonwane Anuj Chauhan Ranvir Singh Pushpendra Kumar Ramji Yadav Mohd Baqir Bharat Bhushan Om Prakash

AIM Toll-like receptor 2 (TLR2) and TLR4 genes play critical roles in host recognition of Mycobacterium bovis infection and initiation of innate and adaptive immune response. The present study was aimed at exploring the association of seven single nucleotide polymorphisms (SNPs) in TLR2 and TLR4 genes with susceptibility/resistance against bovine tuberculosis (bTB) infection in cattle. MATERI...

2017
R Lakshmi KK Jayavardhanan J Thanislass

Mastitis is inflammation of mammary gland characterized by infiltration of leukocytes in udder tissue in response to various bacterial invasions. Staphylococcus aureus is the etiological agent more commonly associated to the disease and is normally related to both subclinical and chronic infections leading to severe economic loss to dairy farms. TLR4 is involved in the initiation of the immune ...

Journal: :Biochemical pharmacology 2005
Joo Y Lee Clifford A Lowell Danielle G Lemay Hyung S Youn Sang H Rhee Kyung H Sohn Byeong Jang Jianping Ye Jin H Chung Daniel H Hwang

Bacterial lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4) leading to the expression of inflammatory gene products. Src-family tyrosine kinases (STKs) are known to be activated by LPS in monocytes/macrophages. Therefore, we determined the role of STKs in TLR4 signaling pathways and target gene expression in macrophages. The activation of NFkappaB, and p38 MAPK, and the expression ...

2014
Theresa Alexandra Mattioli Heather Leduc-Pessah Graham Skelhorne-Gross Christopher J. B. Nicol Brian Milne Tuan Trang Catherine M. Cahill

The innate immune system modulates opioid-induced effects within the central nervous system and one target that has received considerable attention is the toll-like receptor 4 (TLR4). Here, we examined the contribution of TLR4 in the development of morphine tolerance, hyperalgesia, and physical dependence in two inbred mouse strains: C3H/HeJ mice which have a dominant negative point mutation in...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Bernd Krüger Stefanie Krick Navdeep Dhillon Susan M Lerner Scott Ames Jonathan S Bromberg Marvin Lin Liron Walsh John Vella Michael Fischereder Bernhard K Krämer Robert B Colvin Peter S Heeger Barbara T Murphy Bernd Schröppel

While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft injury in human kidney transplants is unknown. Here we show that TLR4 is constitutively expressed within all donor kidneys but is significantly higher in deceased-, compared with living-donor organs. Tubules from dece...

Journal: :The EMBO journal 2010
Wuqiang Fan Hidetaka Morinaga Jane J Kim Eunju Bae Nathanael J Spann Sven Heinz Christopher K Glass Jerrold M Olefsky

The macrophage-mediated inflammatory response is a key etiologic component of obesity-related tissue inflammation and insulin resistance. The transcriptional factor FoxO1 is a key regulator of cell metabolism, cell cycle and cell death. Its activity is tightly regulated by the phosphoinositide-3-kinase-AKT (PI3K-Akt) pathway, which leads to phosphorylation, cytoplasmic retention and inactivatio...

Journal: :Genetics 2006
Donald N Cook Gregory S Whitehead Lauranell H Burch Katherine G Berman Zareen Kapadia Christine Wohlford-Lenane David A Schwartz

Recombinant inbred (RI) mice are frequently used to identify QTL that underlie differences in measurable phenotypes between two inbred strains of mice. Here we show that one RI strain, C57BL/6J x DBA/2J (BXD29), does not develop an inflammatory response following inhalation of LPS. Approximately 25% of F2 mice [F1(BXD29 x DBA/2J) x F1] are also unresponsive to inhaled LPS, suggesting the presen...

2010
Xiaolin Yin Tianwen Hou Ying Liu Jing Chen Zhiyan Yao Cuiqing Ma Lijuan Yang Lin Wei

BACKGROUND Innate immunity of which Toll-like receptor (TLR) 4 and CXCR1 are key elements plays a central role in the development of urinary tract infection (UTI). Although the relation between the genetics of TLR4 and CXCR1 and UTI is investigated partly, the polymorphisms and expression of TLR4 and CXCR1 in different types of UTI in adults are not extremely clear. METHODOLOGY/PRINCIPAL FIND...

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