BACKGROUND Syncope is a common symptom and in most cases it is of a neurally mediated origin. Such patients have to be studied with a careful history and a physical exploration that should include simple maneuvers such as blood pressure (BP) recordings in decubitus and standing position. These tools can suggest diagnosis in a good percentage of patients without the need for expensive or invasiv...

PURPOSE An association between baroreflex sensitivity (BRS) and the response to tilt training has not been reported in patients with neurally mediated syncope (NMS). This study sought to investigate the role of BRS in predicting the response to tilt training in patients with NMS. MATERIALS AND METHODS We analyzed 57 patients who underwent tilt training at our hospital. A responder to tilt tra...

Circulating blood volume is reduced during spaceflight, making astronauts hemodynamically compromised. After landing, astronauts separate into two groups. One group compensates for the hypovolemia with a hyper-sympathetic response during upright tilt testing and can complete a tilt test with few symptoms. The other group is unable to mount a hyper-sympathetic response and experiences orthostati...

BACKGROUND Limited hip extension flexibility due to tight hip flexor musculature or anterior hip capsular and ligamentous structures is a possible cause of increased anterior tilt of the pelvis during running. However, to date, research exploring this relation, as well as the kinematic relation between anterior tilt of the pelvis and peak hip extension range of motion during running, is not ava...

Spaceflight-induced hypovolemia requires astronauts to mount a hyper-sympathetic response in order to complete a tilt test on landing day. We tested the hypothesis that experimentallyinduced hypovolemia, in the absence of spaceflight, also requires a hyper-sympathetic response during tilt. We studied 17 subjects during normovolemia and hypovolemia. Plasma volume, tilt tolerance, supine and stan...

PURPOSE The aim of the study was to randomly compare clomipramine, used as a challenge-agent during head-up tilt test, with isoproterenol, used in the conventional test, in patients with vasovagal syndrome. SUBJECTS AND METHODS The serotonergic re-uptake inhibitor clomipramine was infused (5mg in 5min) at the start of head-up tilt test (Clom-HUT) in 126 patients (mean age 41+/-16 years) with ...