Autoimmune diseases comprise a group of about 85 heterogeneous conditions that can affect virtually any organ and tissue in the body. Many autoimmune diseases change significantly during pregnancy: some ameliorate, some worsen, and others are unaffected. Two autoimmune diseases present prominently in relation to pregnancy: postpartum autoimmune thyroiditis and autoimmune hypophysitis. This arti...

Mycobacterium avium subspecies paratuberculosis (MAP) is the known infectious cause of Johne's disease, an enteric inflammatory disease mostly studied in ruminant animals. MAP has also been implicated in the very similar Crohn's disease of humans as well as sarcoidosis. Recently, MAP has been associated with juvenile sarcoidosis (Blau syndrome), autoimmune diabetes, autoimmune thyroiditis, and ...

Objective: The high incidence of non-organ specific autoantibodies in patients with mitral valve prolapse (MVP) may suggest an association between MVP and autoimmune diseases. A higher incidence of MVP in patients with chronic lymphocytic thyroiditis and Graves’ disease has been demonstrated in various studies. In particular, an increased incidence of MVP in patients with autoimmune thyroid dis...

Previous studies have shown that induction of autoimmune diabetes by adult thymectomy and split dose irradiation of PVG.RT1(u) rats can be prevented by their reconstitution with peripheral CD4(+)CD45RC-TCR-alpha/beta+RT6(+) cells and CD4(+)CD8(-) thymocytes from normal syngeneic donors. These data provide evidence for the role of regulatory T cells in the prevention of a tissue-specific autoimm...

BACKGROUND Numerous genetic studies revealed several susceptibility genes of autoimmune thyroid diseases (AITD), including CTLA4, PTPN22 and FCRL3. These immune-modulating genes are involved in genetic background of AITD among children and adult patients. However, possible age-related differences in overexpression of these genes remain unclear. PURPOSE The goal of this single centre cohort st...

Background Autoimmune hepatitis (AIH) is a progressive inflammatory fribrosing disease of the liver of unknown etiology, which in its normal progress leads to cirrhosis. It is characterized by the increase in aminotranferases and hypergammaglobulinemia, and the presence of nonorgan and specific liver autoantibodies in serum, which allow for its classification. Two subtypes are differentiated: T...

Objective: The relationship between autoimmunity and allergy is well known. The immunoregulation can be modified towards T helper 2 dominance by cytokines and regulatory T cells, which participate in both diseases. Autoimmune thyroid diseases possess different immunoregulatory and sympathoadrenal activity, whose features can be reflected by their association with allergic attacks and the degree...

Objective: This study aims to determine the triggering role of parvovirus B19 (PV-B19) in pathogenesis autoimmune thyroiditis adolescence.Materials and Methods: Thirty-five patients aged 10-18 years who were diagnosed with Hashimoto's last 6 months included study. As control group, 35 healthy volunteers without PV-B19 associated acute disease, no goiter physical examination, family history thyr...

Steroid responsive encephalopathy associated withSteroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT), (also known as Hashimoto's encephalopathy) is a rare autoimmune encephalitis associated with high antithyroid antibodies, and presents with a relapsing-remitting or monophasic course, consisting of confusion, seizures, psychosis, dementia, or stroke-like episodes. I...

OBJECTIVE To report an uncommon presentation of a rare case of autoimmune polyglandular syndrome type IIIb in an elderly woman. CLINICAL PRESENTATION AND INTERVENTION A 62-year-old woman presented with anaemic symptoms and jaundice. Blood tests showed macrocytic anaemia due to vitamin B12 deficiency with Coombs negative haemolysis. A thyroid function test was consistent with hypothyroidism. A...