Introduction Thrombocytopenia is a common laboratory finding among critically ill patients. Studies have shown that thrombocytopenia is associated with increased morbidity and mortality, however there is limited evidence showing increasing mortality with increasing severity of thrombocytopenia. Several risk factors, such as sepsis and surgery, have been associated with thrombocytopenia. The rel...

OBJECTIVE To determine the prevalence of thrombocytopenia in a group of patients suffering from the antiphospholipid syndrome (APS) and to investigate whether these patients may have any particular clinical or serological features. METHODS Retrospective analysis. A group of 171 APS patients seen in our department were studied for the presence of thrombocytopenia. Clinical and serological feat...

conclusions in critically ill patients, the symptoms of hypophosphatemia may not be apparent, but clinicians should be vigilant about this complication during therapy. in cases of severe symptoms (e.g., cardiopulmonary distress, anemia and thrombocytopenia, or rhabdomyolysis), phosphate therapy under close surveillance is warranted. introduction although asymptomatic hypophosphatemia is a commo...

Thrombocytopenia is a well recognized complication of infections, including those from hepatotropic viruses. Thrombocytopenia may actually be the only manifestation of vital hepatitis, which should therefore be considered in the differential diagnosis of primary immune thrombocytopenia (ITP). The mechanisms of thrombocytopenia associated with viral hepatitis vary widely depending on the specifi...

Hereditary thrombocytopenias are rare bleeding disorders, which cause a deficiency of platelets in early infancy. This group of disorders is sometimes associated with abnormal phenotypes, like absence of radius. Diagnosis of this type of thrombocytopenia is usually difficult; other causes of thrombocytopenia, such as immune disorders and infections, must be ruled out. The symptoms of hereditary...

In this issue of Blood, Linkins et al report on a prospective cohort study evaluating the combination of 4Ts (magnitude of thrombocytopenia, timing of onset of thrombocytopenia, thrombosis or other clinical sequelae, and the likelihood of other causes of thrombocytopenia) score and platelet factor 4/heparin particle gel immunoassay (PF4/H-PaGIA) for diagnosis and management of heparin-induced t...

Experimental malarial thrombocytopenia can reach life-threatening levels and is believed to be due to Abs targeting platelets for destruction by the reticuloendothelial system. However, we report that Abs account for at most 15% of platelet destruction as Plasmodium berghei-infected B cell-deficient mice exhibited profound thrombocytopenia (83%) as did C57BL/6 controls (98%). Further, no signif...

abstract objective: to assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. methods: this was prospective study conducted over a period of one year from december 2009 to november 2010 in neonatal intensive care unit of dduh hospital, a tertiary care hospital in delhi, north india. all babies who were admitted during this perio...