INTRODUCTION AND OBJECTIVES We studied genotypic and allelic frequencies of polymorphisms that can affect platelet function, namely the Kozak, VNTR and HPA-2 polymorphisms of glycoprotein Ibα, the Pl(A) polymorphism of glycoprotein IIIa and the C807T polymorphism of glycoprotein Ia, in a Portuguese population composed of 227 donors. METHODS PCR-RFLP was used to assess the Kozak, HPA-2, Pl(A) ...

Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes. Here, we performed forward genetic screening in mice using Sleeping Beauty transposon mutagenesis to identify candidate BC driver genes in an unbiased manner, using a stabilized N-terminal truncated β-catenin gen...

The role of black carbon (BC) aerosols in climate change is important because of its strong capability in causing extinction of solar radiation. A three-dimensional interactive aerosol-climate model has been used to study the climatic impact of BC. The interannual variations of BC solar forcing derived from 20-year transient integrations are up to 4 times as large as the means mainly related to...

background: to study methaemoglobin content and nadh-methaemoglobin reductase activity of three human erythrocyte genotypes (hbaa, hbas and hbss).materials and methods: studies to ascertain methaemoglobin concentration and level of nadh-methaemoglobin reductase activity of three human erythrocyte genotypes (hbaa, hbas and hbss) were carried out in forty-three (43) healthy male participants of c...

We have previously identified numerous tumor-rejection antigens and their epitope peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes (CTLs) in patients with various types of cancer. In the present study, we attempted to determine which antigens and their peptides are useful in specific immunotherapy for bladder carcinoma (BC) patients, especially those with human le...

A BC-tree (block-cutpoint-tree) is a tree (with at least two vertices) where the distance between any two leaves is even. Motivated from the study of the “core” of a graph, BC-trees provide an interesting class of trees. We consider questions related to BC-trees as an effort to make modest progress towards the understanding of this concept. Constructive algorithms are provided for BC-trees with...

The study of human papillomaviruses (HPVs) in cell culture has been hindered because of the difficulty in recreating the three-dimensional structure of the epithelium on which the virus depends to complete its life cycle. Additionally, the study of genetic mutations in the HPV genome and its effects on the viral life cycle are difficult using the current method of transfecting molecularly clone...

In this paper, we describe the WSD team’s approaches to textual entailment recognition task (RITE) at NTCIR-10[1], a conference held in June 18-21, 2013, at NII in Tokyo, Japan, and present experimental results for three Japanese subtasks, called “Binary Class” (BC), “Multi Class” (MC) and “Entrance Exam BC” (ExamBC). Our approach employs two supervised learning techniques: support vector machi...

The big bang-big crunch (BB-BC) algorithm is a popular metaheuristic optimization technique proposed based on one of the theories for the evolution of the universe. The algorithm utilizes a two-phase search mechanism: big-bang phase and big-crunch phase. In the big-bang phase the concept of energy dissipation is considered to produce disorder and randomness in the candidate population while in ...