Three constructs considered to be important primary beliefs in the pathogenesis of OCD are inflated responsibility, intolerance of uncertainty and thought-action fusion. While there is evidence suggesting that these beliefs/appraisals can influence OCD symptoms, we conducted two experiments to determine whether manipulating aversive intrusive thoughts would conversely affect measures of these c...

The native function of α-synuclein is thought to involve regulation of synaptic vesicle trafficking. Recent work has also implicated a role in neurotransmission, possibly through interactions with the proteins involved in synaptic vesicle fusion. Here, we demonstrate that α-synuclein inhibits SNARE-mediated vesicle fusion through binding the membrane, without a direct interaction between α-synu...

The purpose of the present study was to determine the effect of metacognitive therapy (MCT) on symptoms of body dysmorphic disorder (BDD) and on symptoms of thought-fusion, by means of a wait-list controlled clinical trial. Participants were referred from dermatology and cosmetic surgery clinics in the city of Isfahan, Iran, and 20 patients were selected on the basis of DSM-IV-TR diagnostic cri...

BACKGROUND A number of cognitive appraisals have been identified as important in the manifestation of obsessive-compulsive disorder (OCD) in adults. There have, however, been few attempts to explore these cognitive appraisals in clinical groups of young people. METHOD This study compared young people aged between 11 and 18 years with OCD (N = 28), young people with other types of anxiety diso...

Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciproca...

The envelope fusion protein F of Plutella xylostella granulovirus is a computational analogue of the GP64 envelope fusion protein of Autographa californica nucleopolyhedrovirus (AcMNPV). Granulovirus (GV) F proteins were thought to be unable to functionally replace GP64 in the AcMNPV pseudotyping system. In the present study the F protein of Agrotis segetum GV (AgseGV) was identified experiment...

a generalization of the known results in fusion frames and $g$-frames theory to continuous fusion frames which defined by m. h. faroughi and r. ahmadi, is presented in this study. continuous resolution of the identity (cri) is introduced, a new family of cri is constructed, and a number of reconstruction formulas are obtained. also, new results are given on the duality of continuous fusion fram...

abstract  background: spondylolysis and spondylolisthesis can be associated with significant  low back pain, especially in physically active adolescents. non-operative management  is usually successful in improving symptoms, but surgical intervention is  occasionally required. the aim of this study was to determine the effect of in situ posterolateral  fusion in the treatment of refractory case...

splenogonadal fusion is a rare entity with approximately 150 reported cases until the year 2005. the entity is a rare congenital anomaly in which there is fusion of splenic and gonadal anlagen or mesonephric derivatives. splenogonadal fusion has two continuous and discontinuous types. about ten cases have been reported to be associated with bilateral cryptorchidism in literature. very few cases...

Calcium-gated secretion of proteins involves the transfer of "reserve" granules, exocytotic vesicles that are cytoplasmic and, hence, plasma membrane-naive, from the cell interior to the surface membrane where they dock prior to fusion. Docking and subsequent priming steps are thought to require cytoplasmic factors. These steps are believed to induce fusion competence. We have tested this hypot...