SINCE thiouracil was introduced to clinical therapeutics in I943, antithyroid treatment for thyrotoxicosis has widely increased and proved more and more effective as the years have passed, partly as the result of experience but also through the use of more effective agents, such as carbimazole and methimazole. It is thus possible now to assess their relative value in comparison with surgical tr...

When lactating animals are treated with thyroxine, milk yield is almost invariably markedly stimulated (Graham, 1934a, b; Jack & Bechdel, 1935; Folley & White, 1936; Herman, Graham & Turner, 1938; Smith & Dastur, 1940; Owen, 1948a; Chanda & Owen, 1951). Usually the yield of fat is stimulated to a greater extent than that of the milk so that an increase in fat percentage results. This latter eff...

Previous colorimetric methods for the determination of antithyroid compounds of the thiouracil type have been based upon the bluish-green colour which is given when compounds containing the C=S group react with Grote's (1931) reagent. Methods for the determination of thiouracil levels in urine using this reaction have been described by Anderson (1944), Williams, Jandorf, and Kay (1944), Chesley...

The stimulation of ethylene production from seedling tissue of Phascolus vulgaris, Helianthus annuus and Zea mays by growth regulators was inhibited by actinomycin D and puromycin and to a lesser extent by 2-thiouracil and p-fluorophenylalanine. It is concluded that the mechanism of action of growth regulators on the enhancement of ethylene production is the formation of enzymes involved in eth...

The inhibition of flowering of Lemna perpusilla Torr. strain 6746 caused by a light break can be partially reversed by treatment with actinomycin D or 2-thiouracil. Actinomycin D is most active in reversing the response to a light break if the inhibitor is present in the fronds at the time the light break is administered.