Seventy-eight patients were treated with intravesical instillation of Thio-Tepa in an attempt to prevent postoperative recurrences of bladder tumors. Fifty-six patients who were given no preventive treatment against recurrences were taken as the control group. The patients in this series presented at the Okayama University Hospital between 1961 and 1976 and only the first recurrence after the p...

Excision pterygium with bare sclera has an unacceptably high recurrence rate of 30 – 89 %. Different adjunctive treatments have been tried to reduce the recurrence. The use of postoperative beta irradiation leads to severe complications like scleral ulceration, infection and cataract; use of topical thiotepa causes depigmentation of lids. The use of mitomycin C eye drops (0.2 – 0.4 mg/ml) posto...

The cell cycle of the human bladder carcinoma cell line (MGH-U1 cells) was prolonged immediately after low dose of triethylene thiophosphoramide (Thio Tepa). Although the elongated cell cycle time seemed to return to the control level 48 hr following the treatment, there still remained postsynthetic accumulation and postmitotic diminution in the cell population and the cells were insensitive to...

In the title compound, C(15)H(15)N(3)OS, the thio-semicarbazone group adopts an E configuration with respect to the C=N bond. The benzaldehyde thio-semicarbazone fragment is almost planar [maximum deviation = 0.012 (1) Å], while the dihedral angle between the benz-yloxy and phenyl rings is 72.48 (5)°. In the crystal structure, mol-ecules are inter-connected by N-H⋯N and N-H⋯S hydrogen bonds, fo...

By employing a tridentate thiophosphoramide ligand, [(NHAQ)3P[double bond, length as m-dash]S] (AQ = 3-quinolinyl), a cationic MOF, {[Cu6I5(L(1))2](OH)·3DMF·2.5MeOH}n, was synthesized. Photo-physical studies on the 2D-MOF showed an unusual thermochromic behaviour emitting a blue fluorescence at 298 K due to the AQ chromophore and an orange-yellow phosphorescence at 77 K due to the [Cu6I5](+) unit.

Drug-induced cross-links are found in the DNA of chick embryos within 6 hr after injection of mitomycin C and methyl-di-(2-chloroethyl)amine into the egg and 24 hr after injection of triethylene thiophosphoramide. Effects on the rates of synthesis of DNA, RNA, and protein were studied with chemical assays for total content of these macromolecules as well as radioactive precursor incorporation. ...

I1E RECURRING QUESTION its (-alice!i-csearch regat-diing the applicatious of results obtaimsed with atsimal tumssors to the hunsuami problem-is ; the skepticismnn of such applications ofteus expressed by the investigators thennsselves ausd msot immfrequeuntly the aversious showus by sot-inc expeu-ts eungaged its cliurical oncology to data ol)taimred fronns expenimssemst-al caun(-er its amsinsal...

Forty patients with multiple myeloma received thiotepa (750 mg/m2), busulfan (1 0 mg/kg), and cyclophosphamide (1 20 mg/kg) (TBC) followed by autologous bone marrow or blood stem cell support. Granulocyte-Colony stimulating factor (G-CSF) was administered to accelerate hematopoietic recovery. Sixty-five percent of all patients responded to this treatment. Eighty-eight percent of patients transp...