نتایج جستجو برای: thiolated dna

تعداد نتایج: 507855  

Journal: :The Analyst 2008
Claire L Schofield Balaram Mukhopadhyay Sinéad M Hardy Martin B McDonnell Robert A Field David A Russell

Ricin is a toxic lectin which presents a potential security threat. Its rapid detection is highly desirable. Here we present a colorimetric bioassay based on the aggregation of carbohydrate-stabilised gold nanoparticles which has been used to detect Ricinus communis Agglutinin 120 (RCA(120)) - a ricin surrogate. To achieve a stable and robust sensing system the anchor chain length and the densi...

2011
Fatemeh Talaei Ebrahim Azizi Rassoul Dinarvand Fatemeh Atyabi

Thiolated chitosan has high transfection and mucoadhesive properties. We investigated the potential of two recently synthesized polymers: NAC-C (N-acetyl cysteine-chitosan) and NAP-C (N-acetyl penicillamine-chitosan) in anticancer drug delivery targeting epidermal growth factor receptor (EGFR). Doxorubicin (DOX) and antisense oligonucleotide (ASOND)-loaded polymer nanoparticles were prepared in...

2011
Jing Xu Mansoor Amiji

Type B gelatin-based engineered nanovectors system (GENS) was developed for systemic gene delivery in the treatment of pancreatic cancer. The surface of thiolated gelatin nanoparticles was modified with epidermal growth factor receptor (EGFR) specific peptide that targets on the EGFR receptor of Panc-1 cells and this system could release the payload under reducing environment, such as high intr...

2013
Decai Zhang Yurong Yan Wei Cheng Wei Zhang Yahui Li Huangxian Ju Shijia Ding

We are presenting a method for sensitive and specific detection of microRNA (miRNA) using surface plasmon resonance. A thiolated capture DNA probe with a short complete complementary sequence was immobilized on the gold surface of the sensor to recognize the part sequence of target miRNA, and then an oligonucleotide probe linked to streptavidin was employed to bind the another section of the ta...

Journal: :Journal of nanoscience and nanotechnology 2011
Mohammad Ariful Islam Prati Bajracharya Sang-Kee Kang Cheol-Heui Yun Eun-Mi Kim Hwan-Jeong Jeong Yun-Jaie Choi Eun-Bae Kim Chong-Su Cho

In this study, thiolated alginate was synthesized by introduction of cysteine to alginate to prepare mucoadhesive alginate/poly (L-lysine)/thiolated alginate (APTA) microcapsules for efficient oral delivery of Lactobacillus salivarius 29 (LS29), a novel therapeutic Lactobacillus strain, in vitro and in vivo. About 759 +/- 32.4 microM of cysteine per gram of alginate was introduced by estimation...

2017
Gul Shahnaz Benson J Edagwa JoEllyn McMillan Sohail Akhtar Abida Raza Naveeda A Qureshi Masoom Yasinzai Howard E Gendelman

AIM Our goal was to improve treatment outcomes for visceral leishmaniasis by designing nanocarriers that improve drug biodistribution and half-life. Thus, long-acting mannose-anchored thiolated chitosan amphotericin B nanocarrier complexes (MTC AmB) were developed and characterized. MATERIALS & METHODS A mannose-anchored thiolated chitosan nanocarrier was manufactured and characterized. MTC A...

Journal: :Organic & biomolecular chemistry 2013
María J Marín Abdul Rashid Martin Rejzek Shirley A Fairhurst Stephen A Wharton Stephen R Martin John W McCauley Thomas Wileman Robert A Field David A Russell

A plasmonic bioassay for the specific detection of human influenza virus has been developed based on gold nanoparticles functionalised with a designed and synthesised thiolated trivalent α2,6-thio-linked sialic acid derivative. The glyconanoparticles consist of the thiolated trivalent α2,6-thio-linked sialic acid derivative and a thiolated polyethylene glycol (PEG) derivative self-assembled ont...

2014
Ellina A. Mun Claire Hannell Sarah E. Rogers Patrick Hole Adrian C. Williams Vitaliy V. Khutoryanskiy

Understanding nanoparticle diffusion within non-Newtonian biological and synthetic fluids is essential in designing novel formulations (e.g., nanomedicines for drug delivery, shampoos, lotions, coatings, paints, etc.), but is presently poorly defined. This study reports the diffusion of thiolated and PEGylated silica nanoparticles, characterized by small-angle neutron scattering, in solutions o...

Journal: :Chemical communications 2010
Jeremy D Driskell Ralph A Tripp

A silver nanorod array has been used for the intrinsic SERS detection of microRNAs based on different binding affinities of ssRNA, thiolated ssDNA, and the RNA:DNA duplex, eliminating the need for a labelling step.

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