ConceptAnalysisObject) . Here is an issue (specific to Smalltalk because all data are private and we have no ’protected’ keyword) about who use this data: foreign classes or children. If the data is used by children is less painful comparing with the other case. We could find some false negatives among the suspects which were not detected when using the most constrained thresholds but whose Dat...

Background: Metronomic chemotherapy is aimed at lessening the adverse effects of treatment while rendering cancer cells cytostatic. The oral 5-fl uorouracil prodrug “5′-DFUR” has been shown to inhibit angiogenesis and is regarded as a good candidate agent for metronomic chemotherapy. Moreover, cisplatin and 5′-DFUR have been shown to synergistic cytotoxic effects. Methods: We evaluated the safe...

Triclocarban (3,4,4'-trichlorocarbanilide; TCC) is widely used as an antibacterial in bar soaps. During use of these soaps, a significant portion of TCC is absorbed by humans. For the elimination from the body, glucuronidation plays a key role in both biliary and renal clearance. To investigate this metabolic pathway, we performed microsomal incubations of TCC and its hydroxylated metabolites 2...

Uroplakins (UPs) are a group of integral membrane proteins that are synthesized as the major differentiation products of mammalian urothelium. UPII gene expression is bladder specific and differentiation dependent, but very little is known about its transcription response elements. To identify the promoter elements, a DNA fragment of 2239 bp upstream of the UPII gene was amplified by PCR and li...

Changes in cell surface glycosylation occur during the development and differentiation of cells and have been widely correlated with the progression of several diseases. Because of their structural diversity and sensitivity to intraand extracellular conditions, glycans are an indispensable tool for analyzing cellular transformations. Glycans present on the surface of intestinal epithelial cells...

The purpose of this study was to determine whether the reverse abdominal breathing or music intervention before and during mammography decreases the subjective reports of pain and anxiety during screening mammography. A total of 150 subjects were enrolled in this study: 50 subjects in the reverse abdominal breathing group (52.88 ± 6.67 years old), 50 in the music group (50.42 ± 5.54 years old),...