OBJECTIVE Burn wound progression is a poorly understood process by which certain superficial partial-thickness burns spontaneously advance into deep partial-thickness or full-thickness wounds. Progression of an injury into deeper tissue is an important phenomenon in the treatment of thermal injury due to the fact that burn wound depth may be a significant determinant of morbidity and treatment....

-------------------------------------------------------------------------------SUMMARY. The purpose of this experimental study was to evaluate the efficacy of moist exposed bum ointment (MEBO) on epithelial tissue repair and to assess the debriding effect of partial-thickness bum wounds, compared with other local agents commonly used. Eighty bum wounds on ten Ladrace-Pietrenne youngi pigs were ...

Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often influenced by a wide array of experimental variables making it difficult to compare the results across the studies. To mitigate the confounding ...

Methods. After full-thickness, central corneal injury in rabbit eyes, the anterior width of the wound (wound gape) was measured in the same animals using in vivo confocal microscopy. In addition, animals were sacrificed at various times after injury for the determination of aSM actin expression by immunofluorescent microscopy using a mouse monoclonal antibody specific for human a-actin. Antibod...

Background Negative Pressure Wound Therapy (NPWT) is primarily used for very complex chronic wounds. The surgical treatment of the diabetic wounds with loss of soft tissue usually consists of closure using split-thickness skin grafts or transposition flaps. However, the first step consists of standard wound care with moist gauze dressing with the aim to prepare the wound bed for final closure. ...

BACKGROUND In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which will provide the best level of care clinically. Therefore, for paediatric pa...

background: autologous skin graft is frequently used in the field of plastic, and reconstructive surgery. the engraftment is dependent upon revascularization and angiogenesis, which can be regulated by different factors. in addition to its hematopoietic effects, erythropoietin is shown to positively affect the wound healing process. objectives: we studied effects of human erythropoietin on reva...

Partial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified kerat...