نتایج جستجو برای: thermal inhibition

تعداد نتایج: 543669  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Carola Vogel Rainald Mössner Manfred Gerlach Thoralf Heinemann Dennis L Murphy Peter Riederer Klaus-Peter Lesch Claudia Sommer

Antidepressants in the treatment of neuropathic pain are thought to partially exert their effect by inhibition of serotonin (5-HT) reuptake and thus activation of central antinociceptive pathways. Mice deficient for the 5-HT transporter (5-HTT-/- mice) are regarded as a model of lifelong treatment with a serotonin reuptake inhibitor. Here we investigated 5-HTT-/- mice and compared their pain-re...

2016
Ji Hye Baek Kyungsook Kim Soon Sim Yang Seung Hun Park Bo Ram Song Hee-Woong Yun Sung In Jeong Young Jick Kim Byoung Hyun Min Moon Suk Kim

In this study, we examined whether porcine articular cartilage (PAC) is a suitable and effective anti-adhesive material. PAC, which contained no non-collagenous tissue components, was collected by mechanical manipulation and decellularization of porcine knee cartilage. The PAC film for use as an anti-adhesive barrier was easily shaped into various sizes using homemade silicone molds. The PAC fi...

Journal: :Journal of leukocyte biology 1998
M G Schwacha S D Somers

Macrophages (Mphi) have been implicated in the suppression of lymphocyte function following thermal injury. Splenocytes isolated from C57BL/ 6NCR female mice 4-7 days after thermal injury displayed suppressed proliferative responses to Concanavalin A (ConA) and lipopolysaccharide (LPS) and high levels of reactive nitrogen intermediate (RNI) production. Inhibition of nitric oxide synthase activi...

Journal: :Macromolecular rapid communications 2009
Seung Hwan Lee Won Gu Lee Bong Geun Chung Jae Hong Park Ali Khademhosseini

We present a rapid and highly efficient method to form microstructure of poly(ethylene glycol) (PEG)-based acrylates by microwave-induced thermal crosslinking. PEG-based polymeric microstructures such as polymer microarrays and microwells were fabricated on 3-(trimethoxysilyl)propyl methacrylate (TMSPMA)-coated glass slides that were placed on top of a silicon wafer. In comparison to ultraviole...

Journal: :Nucleic acids research 1997
A S Krasilnikov I G Panyutin G M Samadashwily R Cox Y S Lazurkin S M Mirkin

Pyrimidine/purine/purine triplexes are known to inhibit DNA polymerization. Here we have studied the mechanisms of this inhibition by comparing the efficiency of Vent DNA polymerase on triplex- and duplex-containing templates at different temperatures, Mg2+concentrations and time intervals with the thermal stability of the corresponding structures. Our results show that triplexes can only be by...

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