BACKGROUND Carapa procera is a native oil tree species with multipurpose values traditionally exploited by the local population in Southern Mali. This study focused on the assessment of local knowledge about the use of Carapa procera. METHODS Semi-structured ethnobotanical questionnaires were conducted among the ethnic groups Senufo, Fulani and Bambara in two localities in the Sudanian zone i...

A series of novel, saccharin-based antagonists have been identified for the interferon signaling pathway. Through in vitro high-throughput screening with the Colorado Center for Drug Discovery (C2D2) Pilot Library, we identified hit compound 1, which was the basis for extensive structure-activity relationship studies. Our efforts produced a lead anti-inflammatory compound, tert-butyl N-(furan-2...

This article reviews the properties and characterization of an intelligent thermoresponsive surface, which is a key technology for cell sheet-based tissue engineering. Intelligent thermoresponsive surfaces grafted with poly(N-isopropylacrylamide) exhibit hydrophilic/hydrophobic alteration in response to temperature change. Cultured cells are harvested on thermoresponsive cell culture dishes by ...

The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed ...

Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process of selecting an aptamer is called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Thanks to the inherit merits, aptamers have been used in a wide range of applications, including disease diagnosis, targeted delivery agents and therapeutic uses. To...

Throughout history, cannabis has been used as a natural therapeutic herb. Indeed the discovery of the remains of a young girl in Jerusalem who died in childbirth sometime around the third century AD, revealed residues of cannabis in the pelvic region. This strongly suggests that cannabis was used in medical practice in early human civilizations. Cannabis was first used as a medicine in Britain ...

Sargassum species are brown macroalgae found in shallow marine meadows. These are nutritious and rich source of several bioactive compounds. These isolated active compounds exhibit diverse biological activities like antioxidant, antiinflammatory, antipyretic, analgesic, antiviral, antidiabetic, hepatoprotective, anti-obesity, cholinesterase inhibitory activities etc. This makes the Sargassum sp...

This little book gives a short account of cases treated by the author with radium in the hope that it may draw the attention of the general practitioner and student to the conditions in which this valuable therapeutic agent may be of use. The first portion of the work is devoted to a short summary of the physical problems connected with radium, including apparatus, screening, methods of applica...

AIM The aim of this article is to review the current literature on the therapeutic uses and efficacy of Triphala. Herbal remedies are among the most ancient medicines used in traditional systems of healthcare such as Ayurveda. Triphala, a well-recognized and highly efficacious polyherbal Ayurvedic medicine consisting of fruits of the plant species Emblica officinalis (Amalaki), Terminalia belle...

There are occasions when atrial pacing can be usefully employed both diagnostically and therapeutically. Diagnostically, atrial pacing provides mechanisms for easily, safely, and reproducibly stressing the heart that can help in the evaluation of patients with a variety of cardiac disorders. It is particularly useful in the assessment of patients with coronary disease. Therapeutically, atrial p...