A great deal of research has pointed to deleterious roles of metal ions in the development of Alzheimer's disease. These include: i) the precipitation and aggregation of amyloid beta (Abeta) peptides to form senile plaques and neurofibrillary tangles, and/or ii) the augmentation of oxidative stress by metal ion mediated production and activation of hydrogen peroxide. The growing trend in nutrac...

SalNa (sodium salinomycin) reacts with divalent transition metal ions of Co(II), Ni(II), Cu(II) and Zn(II) to produce novel compounds characterized by various spectroscopic methods. The interaction of metal (II) ions with SalNa results in the formation of mononuclear complexes of a general composition of [M(Sal)2·(H2O)2] nH2O (n = 0 or 2) where the divalent cations replace Na ions from the cavi...

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease related to the deposition of aggregated amyloid-β (Aβ) peptides in the brain. It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD progression, especially as metal ions (e.g., Cu(II) and Zn(II)) found in Aβ plaques of the diseased brain can bind to Aβ and be linked to aggregation an...

Crystallins are the predominant proteins of eye lens which prevent heat and oxidative-induced stress-induced aggregation other proteins. They may be classified into two superfamilies, α- βγ- crystallins. The crystallins long-lived structural refract light onto retina. microbial can not only bind to calcium ions, but even able coordinate ions such as Mg2+, Sr2+, Co2+, Mn2+, Ni2+, Zn2+ etc. Such ...

This review focuses on the therapeutic effects of ions when released in physiological environments. Recent studies have shown that metallic like Ag+, Sr2+, Mg2+, Mn2+, Cu2+, Ca2+, P+5, etc., promising results drug delivery systems and regenerative medicine. These can be loaded nanoparticles, mesoporous bioactive glass nanoparticles (MBGNs), hydroxyapatite (HA), calcium phosphates, polymeric coa...

UNLABELLED The wood of mature Abies alba Mill. (silver fir) trees is used in construction and furniture industries, the bark being the main waste product. AIM This study aimed to investigate possible therapeutic applications of Abies alba bark waste. MATERIAL AND METHODS A raw extract and four extractive fractions were obtained from silver fir bark. They were also studied regarding their po...

a batch adsorption study was applied to investigate the adsorption of pb2+ ions from aqueous solutionby nanographene (ng).the adsorption percentage of pb2+ions onto ng samples at different initial ph,contact time (tc), adsorbent dosage (mng) and temperature (t) were investigated. the results showedthat ng is an excellent adsorbent for pb2+ions removal from aqueous solutions with an adsorptionpe...