OBJECTIVES To report on a novel IIF pattern specifically associated with antibodies to DNA topo I. METHODS A novel compound IF pattern, designated Scl-70 pattern, was characterized in routine ANA-HEp-2 IIF screening. Within the last 3 years, all serum samples presenting the Scl-70 pattern at the ANA-HEp2 IIF screening were tested for anti-topo I reactivity. Conversely, 16 serum samples with k...

Systemic sclerosis (SSc) is a connective tissue disease that results in fibrosis in multiple organs. Various animal models for this disease have been developed, both genetic and induced. One of the induced models, sclerodermatous graft-versus-host disease (scl-GvHD), exhibits the main characteristics of SSc, but involves lethal γ-irradiation of recipients. We sought to develop a modified scl-Gv...

The purpose of this study was to examine the SCL-90 profiles of adult outpatients with and without dissociative disorders. A total of 194 participants were administered the Structured Clinical Interview for DSM-IV Dissociative Disorders-Revised (SCID-D-R) and the Symptom Checklist-90 (SCL-90). Patients with dissociative identity disorder (DID) reported significantly higher SCL-90 Global Severit...

Spindle cell lipoma (SCL) is a rare lipoma variant that account for approximately 1.5% of all adipocyte-origin tumors; SCL usually occurs on the posterior neck or shoulder. The histological characteristics of SCL include mature, univacuolar fat cells and fibroblast-like spindle cells in a matrix of collagen and mucoid material. It is important to note that spindle cell lipoma can be mistaken bo...

OBJECTIVES Treatment with Sclerostin antibody (Scl-Ab) has shown to enhance fracture healing in rodent and non-human primate models. The current study investigated the time-dependent changes during Scl-Ab treatment in a mouse osteotomy model. METHODS 1 day after osteotomy, C57BL mice received subcutaneous injection with vehicle or Scl-Ab at 25 mg/kg, twice/week for 2, 4, or 6 weeks. 20 mice f...

Lineage specification and cellular maturation require coordinated regulation of gene expression programs. In large part, this is dependent on the activator and repressor functions of protein complexes associated with tissue-specific transcriptional regulators. In this study, we have used a proteomic approach to characterize multiprotein complexes containing the key hematopoietic regulator SCL i...

Distraction osteogenesis (DO) is a successful technique for bone lengthening, but one problem is the need to keep an external fixator in place until bone completely regenerates. We hypothesized that the systemic administration of sclerostin antibodies (Scl-Ab) can accelerate bone regeneration in a mouse model of DO. A total of 110 mice were randomized to receive one intravenous injection per we...

The Syngas Chemical Looping (SCL) process converts gaseous fuels such as syngas and hydrocarbons into hydrogen and electricity while capturing 100% of the CO2 generated 1, . The SCL process simplifies the overall fuel conversion scheme while reducing pollutants in an indirect but highly effective manner. This is achieved via a specially tailored Fe2O3 based composite particle. As a result, hydr...

Serum Cl (sCl) alterations in hospitalized patients have not been comprehensively studied in recent years. The aim of this study is to investigate the prevalence and outcome significance of (1) sCl alterations on hospital admission, and (2) sCl evolution within the first 48 hr of hospital admission. We conducted a retrospective study of all hospital admissions in the years 2011-2013 at Mayo Cli...

Este estudio tuvo como objetivo evaluar la adecuación del uso de escala SCL-27 (Sympton Checklist-27) en población general y clínica argentina su comparación con el SCL-90R. Se utilizaron una muestra intencional 400 personas 85 pacientes tratamiento psicológico ambulatorio. administraron SCL-27, Mental Health Continuum- Short Form, depresión CES-D, síntomas somáticos Schaffer Satisfacción vida....