Companion diagnostics are integral to the application and success of personalized medicine. In oncology, many companion diagnostics are molecular-based, including a number of fluorescence in situ hybridization (FISH) based companion diagnostics. Here, we review the currently approved FISH based companion diagnostics and evaluate several new FISH assays as potential companion diagnostics.

Virtual companions that interact with users in a socially complex environment require a wide range of social skills. Displaying curiosity is simultaneously a factor to improve a companion’s believability and to unobtrusively affect the user’s activities over time. Curiosity represents a drive to know new things. It is a major driving force for engaging learners in active learning. Existing rese...

In this paper, the notions of pseudofield of values and joint pseudofield of values of matrix polynomials are introduced and some of their algebraic and geometrical properties are studied.  Moreover, the relationship between the pseudofield of values of a matrix polynomial and the pseudofield of values of its companion linearization is stated, and then some properties of the augmented field of ...