regarding increasing rate of drug resistance among microbial pathogens, a global search to find new antimicrobial agents from natural compounds with fewer side effects has been considered by many researchers worldwide. bioactive compounds with good antimicrobial activity have been isolated from different algae and cyanobacteria. the current study was performed to determine antimicrobial potenti...

wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. deoxyvasicinone which wa...

background and objectives:plant essential oils are sometimes considered for use as antimicrobial agents in foods and medicines and they could be combined with other antimicrobial agents to strengthen the effect and/or reduce the required dose. this study was conducted to determine the chemical composition of the ocimum basilicum, salvia officinalis and trachyspermum ammi essential oils and eval...

quinazolinone ring system is renown because of its wide spectrum of pharmacological activities due to various substitutions on this ring system. in this study, the minimum inhibitory concentration of the synthesized compounds in our laboratory was determined by micro dilution alamar blue ® assay against six strains of bacteria (three gram-positive and three gram-negative) and three strains of f...

Euphorbiaceae is a family of plant spread in all parts of the world except very cold regions. The genus Euphorbia consists of over eighty-two species grown wildly in Iran. Some of Euphorbia species are used in the treatment cancer and tumors in different countries. The genus Euphorbia has been the source of a large number of biological active compounds. In this study petroleum ether, ether, eth...

background & aim: in this study, is done during one-year research on blue–green and green algae for antimicrobial activity in mashhad suburb. aqueous, ether, and methanol extracts from 44 species blue – green algae and green algae were examined for antimicrobial properties against four bacteria (tow positive gram bacteria and tow negative gram bacteria) and tow fungous. material & meth...

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...