Ribosomes are molecular machines that function in polyribosome complexes to translate genetic information, guide the synthesis of polypeptides, and modulate the folding of nascent proteins. Here, we report a surprising function for polyribosomes as a result of a systematic examination of the assembly of a large ribonucleoprotein complex, the vault particle. Structural and functional evidence po...

Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known about the function(s) of the vtRNAs or the vault complex. Here, we individually express latent E...

The data vault model natively supports data and schema evolution, so it is often adopted to create operational data stores. However, it can hardly be directly used for OLAP querying. In this paper we propose an approach called Starry Vault for finding a multidimensional structure in data vaults. Starry Vault builds on the specific features of the data vault model to automate multidimensional mo...

--This paper is a brief review of fuzzy vault which is a biometric template security technique. The advent of technology over the last decade has established biometric identification as an electronic equivalent to physical verification. Biometric traits offer a reliable solution to the problem of user authentication in identity management systems. Biometric based authentication has more advanta...

The result of transvaginal sacrospinous ligament fixation technique, as part of the vaginal repair procedure for massive uterovaginal (Pelvic Organ Prolapse stage III and stage IV and vault prolapse) is evaluated. A total of 32 women were included in the present case series. Marked uterovaginal prolapse was present in 28 women and four had vault prolapse following hysterectomy. Patients with va...

We describe a simple and novel cryptographic construction that we refer to as a fuzzy vault. A player Alice may place a secret value κ in a fuzzy vault and “lock” it using a set A of elements from some public universe U . If Bob tries to “unlock” the vault using a set B of similar length, he obtains κ only if B is close to A, i.e., only if A and B overlap substantially. In constrast to previous...

Vaults are cytoplasmic ribonucleoprotein particles composed of three proteins (MVP, TEP1, vPARP) and vault‑associated RNAs (vRNAs). Although the cellular functions of vaults remain unclear, vaults are strongly linked to the development of multidrug resistance (MDR), the major obstacle to the efficient treatment of cancers. Available published data suggest that vaults and their components are fr...

Vaults are the largest known cytoplasmic ribonucleoprotein structures and may function in innate immunity. The vault shell self-assembles from 96 copies of major vault protein and encapsulates two other proteins and a small RNA. We crystallized rat liver vaults and several recombinant vaults, all among the largest non-icosahedral particles to have been crystallized. The best crystals thus far w...

The fuzzy vault is an error tolerant authentication method that ensures the privacy of the stored reference data. Several publications have proposed the application of the fuzzy vault to fingerprints, but the results of subsequent analyses indicate that a single finger does not contain sufficient information for a secure implementation. In this contribution, we present an implementation of a fu...