Further investigation of polar constituents in white lupin roots revealed the presence of genistein 7-O-ß-glucoside (la), genistein 4'-0-ß-glucoside (lb), 2'-hydroxygenistein 7-0ß-glucoside (2a) and 2'-hydroxygenistein 4'-0-ß-glucoside (2b) as simple isoflavone gluco­ sides; luteone 7-O-ß-glucoside (3 a), licoisoflavone A 7-O-ß-glucoside (4 a) and licoisoflavone A 4'-0-ß-glucoside (4b) as preny...

Abstract Introduction Sleep disorders constitute a major public health burden yet remain widely undiagnosed and untreated. The prevalence of diagnosed sleep associations with objectively measured sleep-wake dysfunction vary across populations. Here, we examined the self-reported objective architectural correlates four in large sample individuals using consumer technology. Methods Data from 33,4...

Two isomeric partially acetylated galactocerebrosides, ß-D-galactopyranosyl (2,3,4-tri-O-acetyl)and ß-Dgalactopyranosyl (2,4,6-tri-O-acetyl)-1’(3’-O-acetyl)ceramide, were prepared from galactocerebroside and sulfatide, respectively. Their galactofuranosylation produced ß-D-galactofuranosyl-6and ß-D-galactofuranosyl-3-ß-Dgalactopyranosyl-1’ceramide, as demonstrated by 1 H and 13 C NMR spectra as...

ß-catenin is a key component of the Wnt signaling pathway and the abnormal accumulation of ß-catenin is characteristic of various types of cancer. Here we demonstrate that overexpression of Sox4 enhances ß-catenin/TCF activity by increasing the stability of ß-catenin. Sox4 increased the protein level of ß-catenin and its target gene cyclin D1 in a dose-dependent manner. An siRNA experiment for ...

Litter size is one of the most important economical traits in sheep breeding industry. In addition to minor genes, litter size is under the influence of major genes. Bone morphogenetic protein 15 (BMP-15), a member of the transforming growth factor beta (TGF-ß) superfamily, which is specifically expressed in oocytes, plays a dramatic role in sheep prolificacy. Reported mutations in this gene ca...

Since its discovery and purification in 1971, DNA polymerase ß (Pol ß) is one of the most well-studied DNA polymerases. Pol ß is a key enzyme in the base excision repair (BER) pathway that functions in gap filling DNA synthesis subsequent to the excision of damaged DNA bases. A major focus of our studies is on the cellular roles of Pol ß. We have shown that germline and tumor-associated variant...

ß-Glucogallin (1 -O-galloyl-ß-D-glucopyranose), 1,6-Di-O-galloyl-ß-D-glucopyranose, Acyltransferase, Gallotannin Biosynthesis, Quercus robur Cell-free extracts from oak (Quercus robur) leaves catalyze the transfer of the galloyl-moiety of ß-glucogallin (1-O-galloyl-ß-D-glucopyranose) specifically to the 6-position of the same compound, yielding 1,6-di-O-galloyl-ß-D-glucopyranose, an intermediat...

Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly expressed in adult lung parenchyma following acute lung injury (ALI). Here we report that mice lacking TNC are protected from interstitial fibrosis in the bleomycin model of ALI. Three weeks after exposure to bleomycin, TNC-null mice had accumulated 85% less lung collagen than wild-type mice. The lung in...